The classification of cutaneous lymphomas is multidisciplinary and requires the correlation between clinical, histopathological, immunohistochemical, and molecular diagnostic elements. In this article, we present four different cases of CD30-positive T-cell lymphoma with cutaneous manifestations. We compare cases with definitive diagnosis of papulosis lymphomatoid type C, primary cutaneous anap...

The primary cutaneous CD30-positive (CD30+) T-cell lymphoproliferative disorders are a group of largely indolent diseases that manifest as nodules or tumors of the skin. The European Organisation for Research and Treatment of Cancer (EORTC) has developed a modification of the World Health Organization (WHO) lymphoma classification system that specifically categorizes these entities. According t...

Primary cutaneous anaplastic large T-cell lymphoma CD30+ is a rare lymphoma, which belongs to the group of lymphoproliferations CD30+. It characterized by an excellent prognosis and treatment therefore not very aggressive. However, its histological molecular characteristics have many similarities with lymphoproliferative diseases whose completely different. For this reason, it important study p...

Primary cutaneous lymphomas differ significantly from their nodal equivalents in clinical behaviour and prognosis, and often require a different therapeutic approach. Since currently used classification systems for non-Hodgkin lymphomas do not or insufficiently recognize the special character of these lymphomas, primary cutaneous lymphomas are not uncommonly diagnosed incorrectly, and/or treate...

Primary cutaneous anaplastic large cell lymphoma is a T-cell malignancy with atypical CD30 positive lymphocytes. Pseudoepitheliomatous hyperplasia is an uncommon finding in primary cutaneous anaplastic large cell lymphoma, and may mimic squamous cell carcinoma as pseudomalignancy. Careful attention of a pathologist to correct diagnosis of pseudoepitheliomatous hyperplasia and its underlying cau...

ALCL: anaplastic large cell lymphoma CL: composite lymphoma EBV: Epstein-Barr virus MF: mycosis fungoides INTRODUCTION Patients with mycosis fungoides (MF) are at increased risk of a second malignant neoplasm, especially lymphoma. We report a sexagenarian with a 14-year history of patch MF, stage IB, who had intravascular cutaneous anaplastic large cell lymphoma (ALCL) and cutaneous composite l...