Chequerboard titrations were used to test the activity of trovafloxacin, alone and in combination with clindamycin or metronidazole, against 156 Gram-positive or Gram-negative anaerobes, including 47 Bacteroides fragilis group, 36 Prevotella spp., 26 fusobacteria, 21 peptostreptococci and 26 clostridia. MIC50/MIC90 values (mg/L) of each drug alone against all 156 strains were: trovafloxacin, 0....

Numerous studies have associated alterations in the gut microbiota composition with almost every known inflammatory disease. However, proving biological relevance of distinct microbial signatures and linking specific microorganisms to host phenotypes, remains a considerable challenge. Correspondingly, increased abundance members Prevotella genus within communities colonizing mucosal surfaces ha...

Deciphering the key factors underlying individual responses to a habitual diet is important in implementing personalized nutrition strategies treat allergic diseases. This prospective randomized cohort study aimed identify determining pollen allergy (PA) trajectories natural setting. Baseline data on fecal microbiota composition, lifestyle activities, and habits of 190 participants with PA 92 h...

This study investigated the ability of anaerobic periodontal bacteria to inactivate and resist killing by antimicrobial peptides through production of extracellular proteases. Antibacterial activities of peptides were assessed in a double-layer agarose diffusion assay, and MICs and MBCs were determined in broth microdilution assays. Culture supernates of Porphyromonas gingivalis and Prevotella ...

The purpose of this study was to examine host distribution patterns among fecal bacteria in the order Bacteroidales, with the goal of using endemic sequences as markers for fecal source identification in aquatic environments. We analyzed Bacteroidales 16S rRNA gene sequences from the feces of eight hosts: human, bovine, pig, horse, dog, cat, gull, and elk. Recovered sequences did not match data...

We describe a case of vertebral osteomyelitis caused by Prevotella intermedia, which is an extremely unusual cause of vertebral osteomyelitis. The organism was isolated from vertebral biopsies and the patient was treated successfully with intravenous ampicillin-sulbactam and clindamycin. Diagnosis and management of this condition are described, and the importance of anaerobic bacteria in the pa...

Hypertension is a severe public health problem due to its high prevalence worldwide. About 7.5 million deaths or 12.8% of all annual worldwide occur blood pressure. The hypertensive disease also associated with the intestinal bacteria. To our knowledge, diversity gut bacteria in patients has not been reported yet Indonesia. Thus, aims this study were analyze profile compared non-hypertensive ba...