Primaquine phosphate has been used for preventing relapse of Plasmodium vivax and P. ovale malaria since the early 1950s, based on its ability to kill latent (hypnozoite) and developing liver stages of these parasites. There are three uses for primaquine in malaria: radical cure of established infection with P. vivax or P. ovale malaria; presumptive anti-relapse therapy (PART; terminal prophyla...

Background: Uganda has some of the highest reported malaria transmission rates in the world. Methods: We reviewed published and un-published reports to provide a historical perspective and evolution of malaria case management strategies/policies in Uganda. Review findings: In the 1990s, uncomplicated malaria treatment was hampered by widespread parasite resistance to chloroquine (CQ) and sulpha...

Medical care of populations often treads a fine line between the differing harms of underdiagnosis and overdiagnosis. Underdiagnosis may mean that a disease is advanced by the time it is detected, increasing the risk of death, whereas overdiagnosis leads to healthy people being labelled as sick and treated with drugs that will be of no benefit and may even cause harm. How much underdiagnosis or...

Malaria and pneumonia are leading causes of childhood mortality. Home Management of fever as Malaria (HMM) enables presumptive treatment with antimalarial drugs but excludes pneumonia. We aimed to evaluate the impact of adding an antibiotic, amoxicillin (AMX) to an antimalarial, artesunate amodiaquine (AAQ + AMX) for treating fever among children 2-59 months of age within the HMM strategy on al...

Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...

Dengue is one of the most common arthropod-borne viral diseases in humans and it is a leading cause of illness and death in the tropical and subtropical regions of the world. It is thought to account for 400 million cases annually among approximately 3.97 billion people at risk of infection in 128 endemic countries. Despite the global prevalence of the disease, the availability of a vaccine is ...

A randomized, double-blinded, placebo-controlled study was conducted to examine the effect of spatial repellent (SR) in households at risk of malaria in Indonesia. Following presumptive radical cure for malaria in 180 adult men representing sentinels of new infection in four clusters within two villages, all households were given either metofluthrin or placebo mosquito coils. Weekly blood smear...

background: evaluating the malaria status of the economic cooperation organization (eco) member countries relation to goal 6 of 3rd millennium development goals (mdgs) which includes have halted by 2015 and begun to reverse the incidence of malaria. methods: by 2009, we reviewed the mdgs reports, extracted the data from surveillance system, published, and unpublished data. the main stakeholders...

malaria is a parasitic disease that is starting to be encountered in intensive care units (icu) worldwide, owing to increasing globalisation. severe malaria caused by plasmodium falciparum , is characterised by cerebral malaria, acute renal failure, hypoglycaemia, severe anaemia, splenomegaly and alveolar oedema. we present the case of a 25-yr old male patient who presented to the emergency dep...