TiE relationship between changes in pressure and changes in volume within the eye is of practical importance in the calibration of tonometers and in tonographic calculations, and the coefficient of ocular rigidity, K, proposed by Friedenwald (1937) has been employed generally for these purposes. Contrary to Friedenwald's assertion, it has been found that this coefficient is not a constant, but ...

A quasi-two-dimensional equation of state for liquid-type lipid monolayers has been derived and successfully applied to surface pressure-area isotherms obtained with a variety of lipids. For lipids with acyl moieties of similar length, the surface pressure and area at monolayer collapse can be accurately predicted from data obtained at lower surface pressure. Consideration of the rationalized a...

Hypercapnic acidosis (HCA) has beneficial effects in experimental models of lung injury by attenuating inflammation and decreasing pulmonary edema. However, HCA increases pulmonary vascular pressure that will increase fluid filtration and worsen edema development. To reconcile these disparate effects, we tested the hypothesis that HCA inhibits endothelial mechanotransduction and protects agains...

The pressure-flow characteristics of 100 left circumflex stenoses in 10 chronically instrumented unsedated dogs were studied under resting conditions and during pharmacological coronary vasodilation. At rest, the pressure loss (deltaP) due to a stenosis and arterial flow velocity (V) were related by the equation, deltaP = FV + SV2, where F is the coefficient of pressure loss due to viscous fric...