OBJECTIVE Unfavorable socioeconomic status (SES) circumstances early in life are associated with heightened vulnerability to respiratory and cardiovascular diseases in adulthood. However, little is known about mechanisms underlying this phenomenon. METHODS This study examined whether early-life SES predicts future activity of two genes involved in regulating inflammation. An ethnically divers...

Gamma index pass rates were evaluated for an anthropomorphic phantom using both 2D and 3D calculations. The phantom was irradiated with the traditional dosimetry insert loaded with radiochromic film and TLD, and then with a 3D dosimetry insert. A comparison with the calculated dose distribution showed that both the PRESAGE® dosimeter and the film and TLD system agreed with the plan to within 5%...

Modern brain technology is a highly dynamic and innovative field of research with great potential for medical applications. Recent advances in recording neural signals from the brain by brain-machine interfacing presage new therapeutic options for paralyzed people by means of neural motor prostheses. This paper examines foreseeable ethical questions related to the research on brainmachine inter...

Hydrogen peroxide (H2O2) is emerging as a newly recognized messenger in cellular signal transduction. However, a substantial challenge in elucidating its diverse roles in complex biological environments is the lack of methods for probing this reactive oxygen metabolite in living systems with molecular specificity. Here we report the synthesis and application of Peroxy Green 1 (PG1) and Peroxy C...

Cognitive remediation is a treatment approach with the potential to translate basic science into more specific, mechanism-based interventions by targeting particular cognitive skills. The present study translated understanding of two well-defined cognitive-affective dysfunctions into novel deficit-matched interventions and evaluated whether cognitive remediation would demonstrate specific and g...

Mounting evidence connects the biomechanical properties of tissues to the development of eye diseases such as keratoconus, a common disease in which the cornea thins and bulges into a conical shape. However, measuring biomechanical changes in vivo with sufficient sensitivity for disease detection has proved challenging. Here, we present a first largescale study (~200 subjects, including normal ...

Process models are used by information professionals to convey semantics about the business operations in a real-world domain that are intended to be supported by an information system. The understandability of these models is vital to them actually being used. Until now, understandability has primarily been defined as an intrinsic quality of the models themselves. In this paper we conceptualiz...

The species of the genus Rauvolfia are a reservoir indole alkaloids with proven pharmacological properties. A chloroform extract root bark vomitoria (Apocynaceae) was studied. phytochemical investigation said allowed isolated four indolic alkaloids, three which known (Reserpine, ajmaline and mauiensine) unknown phyto-constituent (3). In addition, methyl esters 3, 4, 5-trimethoxybenzoic acid (Ph...

Sixteen pandemic months have felt disorienting and arduous—but along the arc of human history, COVID-19 marks just another inflection point. Epidemics punctuated humanity9s timeline for centuries, sowing panic killing millions people, whether culprit was plague or smallpox influenza. And when infections abate, their imprints on society can remain, some short-lived enduring. In a series news art...