ZONDEK [1934] reported the preparation of crude alcoholic eXtracts of horse testes which possessed a marked oestrogenic potency. Extracts obtained in this way were three hundred times as active oestrogenically as those prepared from a similar weight of mares' ovaries. The high oestrogenic potency of horse testes extracts has been confirmed by later workers. The present investigation was underta...

Alpha-Hydroxy ketones with an aromatic and aliphatic substituent were prepared with condensation of aromatic and aliphatic aldehydes in the presence of polymer-bound thiazolium salt.

Ketones have previously shown beneficial effects in models of neurodegenerative disorders, particularly against associated mitochondrial dysfunction and cognitive impairment. However, evidence of a synaptic protective effect of ketones remains lacking. We tested the effects of ketones on synaptic impairment induced by mitochondrial respiratory complex (MRC) inhibitors using electrophysiological...

Functionalized chiral ketones, such as a-amino ketones, bnitro ketones, and their derivatives, are prevalent building blocks and ubiquitous subunits present in natural products and pharmaceutical lead compunds. The synthesis of chiral ketones can be achieved through direct a substitution. For example, the synthesis of a-amino ketones has been developed by Jørgensen and co-workers using an elega...

spiro-4- thiazolidinones have been synthesized by the cyclocondensation of phthalazinyl hydrazones with cyclic ketones and substituted mercapto acetic acids. compounds were screened for their antibacterial, antifungal and antihypertensive activity. the combined elemental analyses and spectroscopic data prove the authenticity of the synthesized compounds

1,1-diacetates(acylals) were prepared by direct condensation of various aldehydes with acetic anhydride using dipyridine cobalt chloride (copy2cl2) as an efficient and green catalyst under solvent-free conditions at room temperature. the important features of this catalyst method are that the catalyst is solid, stable at high temperatures, soluble in water, stable in air, immiscible in common o...

nBu4NI-Catalyzed oxidative imidation of ketones and imides for the synthesis of α-amino ketones were realized for the first time. The methodology is characterized by its wide substrate scope even for acetone with readily available phthalimide, saccharin and succinimide, which opens a new pathway for direct imidation of ketones.