OBJECTIVE To estimate the difference between levels of the two biochemical markers pregnancy-associated plasma protein-A (PAPP-A) and maternal serum free β-human chorionic gonadotropin (free β-hCG) in twin pregnancies relative to singleton pregnancies and establish an improved screening procedure for chromosomal abnormalities such as trisomy 21 in twin pregnancies. METHODS 4843 unaffected and...

OBJECTIVE To examine birth weight in pregnancies with isolated single umbilical artery (ISUA). METHODS Case control study with retrospective review of 131 singleton pregnancies with isolated single umbilical artery diagnosed before birth. Control group consisted of 730 singleton pregnancies recruited prospectively, that had histological confirmation of a 3 vessels cord. Pregnancies were class...

OBJECTIVE To report the outcome of monochorionic (MC) and dichorionic (DC) triamniotic (TA) triplet pregnancies treated with endoscopic laser coagulation of the communicating placental vessels for severe feto-fetal transfusion syndrome (FFTS) and selective fetal growth restriction (sFGR). METHODS Laser surgery was performed at 18 (15-24) weeks' gestation in 11 MCTA and 33 DCTA pregnancies com...

BACKGROUND Egg donation (ED) makes it possible for subfertile women to conceive. Pregnancies achieved using ED with unrelated donors are unique, since the entire fetal genome is allogeneic to the mother. The aims of this review were to evaluate the consequences of ED pregnancies and to place them in the special context of their atypical immunologic relationships. METHODS This review comprised...

OBJECTIVE To assess the effects of semen characteristics on the success of intrauterine insemination (IUI). DESIGN A retrospective study. SETTINGS The Department of Obstetrics and Gynecology, Tokushima University Hospital, Japan. PATIENTS Between 2004 and 2008, 1,177 IUI cycles in 283 couples were studied. INTERVENTION IUI cycles were preceded with ovarian stimulation. MAIN OUTCOME ME...

Background: Pregnant women with cardiovascular diseases (CVD) and their offspring are at higher risk of morbidity mortality. Aims: To provide data on pregnancy outcomes among different types CVD requiring non-elective cardiac hospitalization in a tertiary referral center. Methods: We identified all records hospitalizations pregnant hospitalized between January 2009 through March 2018, our insti...

Dear Editor-in-Chief The recent report on “The Adverse Effects of Pregnancies Complicated by Hemoglobin H (HBH) Disease” is very interesting (1). Rabiee et al. reported a pregnant case complicated with HBH disease. Indeed, this problem might not common in the Middle East but it is very common in Southeast Asia. The authors hereby would like to share the experience on this top...

drug abuse in pregnancy is not uncommon, and the use of illicit opioids during pregnancy is associated with an increased risk of adverse outcomes. the aim of the study was to assess neonatal outcome of pregnancy with maternal addiction. materials and methods:   in this cohort study we assessed 100 pregnant women 15 -49 years old. to identify drug exposure was used self- questionnaire (self-repo...