T cell activation after contact with an antigen-presenting cell depends on the regulated assembly of the T cell receptor signaling complex, which involves the polarized assembly of a stable, raft-like macrodomain surrounding engaged T cell receptors. Here we show that the preformed reggie/flotillin caps present in resting T cells act as priming platforms for macrodomain assembly. Preformed regg...

L IVER ALLOGRAfTS are resistant to hyperacute or antibody mediated rejection from preformed antibodies. No consistent syndrome develops following transplantation when a recipient harbors preformed Iymphocytotoxic antibodies.1.2 The only apparent deleterious effect of preformed Iymphocytotoxic antibodies is a higher incidence of the "vanishing hile duct syndrome.") Despite these clinical observa...

In this paper we propose a scaling argument to quantify the role of added electrolyte salt in affecting the stability and the morphology of preformed surface nanobubbles on hydrophobic substrates like the water-OTS-silicon or the water-HOPG interfaces. The added salt controls the electric double layer formation as well as affects the zeta (ζ) potential at the air-water and solid-water interface...

CD40 ligand (CD40L) is an essential effector cytokine for macrophage activation, dendritic cell licensing, and T-cell-dependent antibody responses. Although CD40L is known to be made de novo following antigen recognition, several reports have described surface mobilization of preformed, intracellular CD40L in certain CD4(+) effector T cells. Here we show that rapid surface expression of preform...

pp/pep blends, because of different solubility factors, are incompatible. the aim of this research was to use pp-g-ma compatibilizer in a two-component blend. after preparing this compatibilizer in internal mixer and investigating different parameters on producing process, optimum compatibilization was obtained. pp/pet (60/40) blend fibers with different percentages of this compatibilizer in tw...

Patients with elevated levels of preformed reactive antibodies to HLA antigens have higher rates of organ rejection than do patients without such antibodies. Consequently, before proceeding with transplantation, many medical centers do prospective cross-matching, that is, mix lymphocytes from the organ donor with sera from the prospective organ recipient, to determine whether a higher rejection...

BACKGROUND Retrospective studies have suggested that routine use of a preformed silo for infants with gastroschisis may be associated with improved outcomes. We performed a prospective multicenter randomized controlled trial to test this hypothesis. METHODS Eligible infants were randomized to (1) routine bedside placement of a preformed Silastic spring-loaded silo, with gradual reduction and ...

Membrane vesicles composed of fatty acids can be made to grow and divide under laboratory conditions, and thus provide a model system relevant to the emergence of cellular life. Fatty acid vesicles grow spontaneously when alkaline micelles are added to buffered vesicles. To investigate the mechanism of this process, we used stopped-flow kinetics to analyze the dilution of non-exchanging FRET pr...

OBJECTIVE The most accurate orbital reconstructions result from an anatomic repair of the premorbid orbital architecture. Many different techniques and materials have been used; unfortunately, there is currently no optimal method. This study compares the use of preformed vs intraoperative bending of titanium mesh for orbital reconstruction in 2-wall orbital fractures. STUDY DESIGN Cadaver-bas...

Waste fibers produced from manufacturing processes are a byproduct commonly deposited in storing yards and/or landfills and thus results in many serious environmental problems in Iran. If these waste materials could be advantageously put to practical use in any application, it would reduce the burden on the environment and landfills. This paper compares the performance of the stone matrix aspha...