Nitric oxide (NO) is implicated in triggering and mediating delayed preconditioning. However, the role of NO and endothelial nitric oxide synthase (eNOS) in early ischaemic preconditioning is controversial. To investigate the role of eNOS in this paradigm further, the response of hearts isolated from either eNOS knockout (KO) or eNOS wild type (WT) mice to various ischaemic-preconditioning stim...

We present a class of parallel preconditioning strategies utilizing multilevel block incomplete LU (ILU) factorization techniques to solve large sparse linear systems. The preconditioners are constructed by exploiting the concept of block independent sets (BISs). Two algorithms for constructing BISs of a sparse matrix in a distributed environment are proposed. We compare a few implementations o...

Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechan...

objective(s)ischemia-reperfusion injury (iri) is a leading cause of kidney transplantation failure, and ischemic-preconditioning (ipc) is a protective method against the iri. in the present study, the defensive effect of ipc on rats’ kidney was investigated and more importantly the differences between two genders were appraised.materials and methodsthirty two wistar rats were randomly allocated...

The phenomenon of ischemic preconditioning, in which a period of sublethal ischemia can profoundly protect the cell from infarction during a subsequent ischemic insult, has been responsible for an enormous amount of research over the last 15 years. Ischemic preconditioning is associated with two forms of protection: a classical form lasting approximately 2 h after the preconditioning ischemia f...

Objective: To study the therapeutic effects of moxibustion preconditioning on cerebral ischemia-reperfusion injury in rats. Methods: One hundred and thirty healthy male Wistar rats were selected and randomly divided into five groups: electroacupuncture preconditioning group (n=30) and moxibustion preconditioning group (n=30), aspirin preconditioning group (n=30), model group (n=30) and blank co...

BACKGROUND The ischemic preconditioning response among elderly patients is known to be lower than in adult patients. Since mitochondrial ATP-sensitive potassium (K(ATP)) channels exert preconditioning effects, we undertook this study to determine whether this attenuated activation of K(ATP) channels influences the reduced responsiveness of elderly patients to ischemic preconditioning. METHODS...

We take a fairly comprehensive approach to the problem of solving elliptic partial differential equations numerically using integral equation methods on domains where the boundary has a large number of corners and branching points. Use of non-standard integral equations, graded meshes, interpolatory quadrature, and compressed inverse preconditioning are techniques that are explored, developed, ...

Frequency domain formulations of computational electromagnetic problems often require the solutions of complex-valued non-Hermitian systems of equations, which are still symmetric. For this kind of problems a whole class of sub-variant solver methods derived from the complex-valued Bi-Conjugate Gradient method is available. This class of methods contains established solution methods as the Conj...