During the 2015 State of the Union address, President Obama unveiled plans for a $215 million Precision Medicine Initiative. The details of this plan were laid out by past and present directors of the National Institutes of Health, Harold Varmus and Francis Collins, in a commentary in the New England Journal of Medicine. While the announcement stood as a public statement of support for funding,...

The Cell Index Database, (CELLX) (http://cellx.sourceforge.net) provides a computational framework for integrating expression, copy number variation, mutation, compound activity, and meta data from cancer cells. CELLX provides the computational biologist a quick way to perform routine analyses as well as the means to rapidly integrate data for offline analysis. Data is accessible through a web ...

In this paper we examine an alternative interface for phonetic search, namely query-by-example, that avoids OOV issues associated with both standard word-based and phonetic search methods. We develop three methods that compare query lattices derived from example audio against a standard ngrambased phonetic index and we analyze factors affecting the performance of these systems. We show that the...

Across a broad range of disciplines, the accurate determination of an electromagnetic wave's amplitude (either absolute or relative) has considerable relevance. Here, we demonstrate a novel and potentially very precise method for making intensity measurements based on the atomic stabilization of electromagnetic field-strength. For ease of reference, and by analogy to atomic clocks, we refer to ...

In this Letter we report on fabricating and analyzing a temperature insensitive refractometer based on two concatenated dual-resonance long-period gratings (LPGs) with an appropriate inter-grating space (IGS) in between. The IGS provides a temperature-dependent extra phase difference between the core and cladding modes, making the refractometer similar to a Mach-Zehnder interferometer with its ...

The contribution of the thromboplastin international sensitivity index (ISI) to the interlaboratory coefficient of variation (CV) of the international normalised ratio (INR) with individual reagents was assessed. In theory the precision of the INR should increase with lower ISI values. An empirical relation has been established between the ISI, the INR, and its CV for two rabbit thromboplastins...

the emerging concept of personalized medicine or precision medicine has recently become more popular both among the health-care providers and patients. the focus of personalized medicine is to target prevention and treatment strategies based on patients’ variability in genotype, environment and lifestyle. since precision medicine will make the clinical guidelines much more conditional and branc...

OBJECTIVE Despite the advantages of structured data entry, much of the patient record is still stored as unstructured or semistructured narrative text. The issue of representing clinical document content remains problematic. The authors' prior work using an automated UMLS document indexing system has been encouraging but has been affected by the generally low indexing precision of such systems....

We investigate van Rijsbergen’s -measure, break-even point, and 11-point averaged precision, all of which can be translated into 1-dimensional scalar quantity from the precision and the recall. These investigations can be done by comparing to tetrachoric (four-fold) correlation coefficient and phi (four-fold point) coefficient, which are often used as the index of statistical association in a 2...

We present a laser-based system to measure the refractive index of air over a long path length. In optical distance measurements, it is essential to know the refractive index of air with high accuracy. Commonly, the refractive index of air is calculated from the properties of the ambient air using either Ciddor or Edlén equations, where the dominant uncertainty component is in most cases the ai...