Cytologic screening is an important diagnostic tool used to detect precancerous and cancerous lesions of the cervix. We studied the prevalence of cervical abnormalities, based on Pap smear results, in patients at the Outpatient Adolescent Clinic at West Virginia University. We found a high incidence of overall intraepithelial cell pathology (24%) in this group with 2.4% high grade and 9.9% low-...

We appreciate the interest of Drs. Garner, Guillaud, and MacAulay in our work and thank them for their critical comments on our recent publication (1). Early detection of cancerous lesions is a pivotal step for reducing cervical cancer–associated mortality. Finding a method which possesses high sensitivity and specificity in screening of mass populations has been difficult for cancer researcher...

conclusions since ki-67 is extensively accepted as an important biomarker in diagnosis, prognosis and treatment of cancerous and precancerous lesions, a high degree of presence of this biomarker in chronic precancerous lesions, such as erosive olp, can be of great use in prognosis and suggested treatments. objectives this study aimed to evaluate ki-67 expression in erosive and non-erosive oral ...

Cervical cancer is the second most common gynecologic cancer worldwide. Unlike the other cancers it does not show any symptoms in its earlier stage which causes mortality among women. It takes 8 to 10 years to develop from precancerous to severe stage. The important reasons for higher cervical cancer in developing countries are lack of resources, lack of effectual screening programs and inadequ...

Technology in healthcare is one of the emerging applications areas. Women in remote areas of developing nations are subject to lack of adequate healthcare facilities and specialist doctors. One of the commonest forms of cancer in women worldwide is Uterine Cervical Cancer. Most cases of cervical cancer can be prevented through screening programs aimed at detecting precancerous lesions. Due to l...

Gastric carcinoma is a common malignant disease associated with an unfavorable prognosis in the case of late dia-gnosis. The most significant precancerous condition is chronic atrophic gastritis and intestinal metaplasia caused by Helicobacter pylori infection. These longlasting changes may lead to formation of dysplastic precancerous lesions. Upper endoscopy and histologic examination of force...

Introduction: Cervical screening would benefit from a test based on a disease-specific biomarker that identifies high grade lesions, which could also indicate the presence of early precancerous lesions that have a high risk of progression to cancer. One such potential biomarker is p16INK4A. Objective of the study was to study the biomarker p16INK4A expression by immunostaining in cervical intra...

Colorectal cancer (CRC) is a common and often lethal tumor. Over the last 25 years, remarkable progress has been made in understanding its biological and molecular features and in elucidating the steps involved in colon carcinogenesis. This, in turn, has led to a more rational and effective clinical approach to the treatment of CRC. While colorectal adenoma is the most frequent precancerous les...

Oral cancer continues to be a serious problem in the UK and it is well known that prevention and early recognition of potentially malignant lesions will provide the best prognosis. This article discusses recent changes in the nomenclature of lesions and current concepts in diagnosis and management.