Background: Organophosphates are pesticides that are used widely in agriculture and industry. Because of the ease of access and abundant use of these pesticides, many cases of intentional and accidental poisoning of these compounds are reported. The aim of this comprehensive study was to evaluate the symptoms and treatment of patients referred to Razi hospital as the main center for poisoning i...

The pharmacokinetics and cardiovascular pharmacodynamics of two oximes were studied in unanesthetized pigs. Effects of 2-[(hydroxyimino)methyl]-1-methylpyridinium chloride (pralidoxime chloride; 2-PAM Cl; 50 mumol/kg) were compared with those of 1,1-methylene bis[4(hydroxyiminomethyl) pyridinium] dichloride (methoxime; MMB-4; 100 mumol/kg). Cardiopulmonary parameters were monitored and plasma c...

Organophosphate (OP) compounds are among the most lethal chemical weapons ever developed and are irreversible inhibitors of acetylcholinesterase. Exposure to majority of OP produces status epilepticus (SE) and severe cholinergic symptoms that if left untreated are fatal. Survivors of OP intoxication often suffer from irreversible brain damage and chronic neurological disorders. Although pilocar...

Active acid protease was found in serum-free spent medium of human pancreatic carcinoma cell line HPC-YT. These cells have been maintained for over 215 generations in a serum-free, chemically defined medium. Acid protease was partially purified about 3000-fold by Mono Q ion-exchange chromatography, pepstatin-aminohexyl-Sepharose affinity chromatography, hydroxylapatite affinity chromatography, ...

BACKGROUND Hexachlorobenzene (HCB) and other organochlorines induce porphyria cutanea tarda (PCT) in animal studies. Evidence in humans, however, is contradictory. In neonates and adults from a population historically highly exposed to HCB (Flix, Catalonia, Spain), no relation with PCT or with porphyrin excretion was found. OBJECTIVES We aimed to analyze the association between urinary porphy...

Musk xylene (MX), musk ketone (MK), musk ambrette, musk moskene, and musk tibetene are synthetic fragrances. Between 1994 and 1996 these five nitromusk compounds (NMCs) were tested in the blood of 152 women who consulted the Endocrinological Department of the University Hospital of Obstetrics and Gynecology, Heidelberg, Germany, because of gynecological problems. The testing was conducted by ga...

Background: Organophosphorus compound ingestion is one of the most common modes of deliberate self-harm in developing countries like India. Neurological complications are known in acute, intermediate and delayed phases following organophosphate poisoning. However, extrapyramidal manifestations are rarely reported. Case presentation: A 30-year-old male patient was brought...

We studied the effect of temperature (18 and 30°C) on growth and on the exploitation and interference competition of three species: Microcystis aeruginosa (MIJAC), Planktothrix agardhii (PAT), and Cyclotella meneghiniana (CCAP). Coculturing the organisms in batch systems allowed for the examination of both competitive interactions, while the interference competition was studied in cross-culture...