Weinblatt ME, Bingham CO, Mendelsohn AM, et al. Ann Rheum Dis (2012). doi:10.1136/annrheumdis-2012-201411 1 of 9 and anti-TNF-experienced4 patients with RA when administered monthly via subcutaneous injection. Intravenous administration of golimumab every 12 weeks (q12 weeks) was previously assessed in a phase 3 trial in patients with RA, with persistent disease despite MTX therapy.5 While the ...

This issue of The Journal of Laryngology & Otology features two review articles that focus on areas of basic research in our specialty. Wormald and colleagues review the topic of regenerative medicine. Tissue engineering holds great potential to restore structure and function following resection for disease or congenital abnormality, with tracheal regeneration being at the forefront. This type ...

become senseless and incapable of reason." Aristotle's implication that the deaf could not possibly be taught to speak rendered them a tremendous disservice, since the next two thousand years of Christendom were to "live and die in Aristotle's works," and no educated man would waste his time and strength in essaying an acknowledged impossibility. The whole future of the deaf depended on the adv...

On September 21 and 22, 2006, the National Institute of Child Health and Human Development of the National Institutes of Health sponsored a 2-day workshop titled "Preeclampsia--A Pressing Problem." The purpose of the workshop was to bring together leaders in the field to present and discuss their diverse research areas, which ranged from basic science to clinical trials and management, and to i...

The fourth EMBO conference on 'The Molecular and Cellular Basis of Regeneration and Repair', held in September 2012, brought together researchers from both the regeneration and wound-healing fields. The meeting spanned a wide range of research topics from basic science to clinical application, and a veritable melting pot of model organisms and approaches resulted in an excellent fourth conferen...

Neuroscience has fundamentally changed the understanding of learning and memory within recent years. Here, the authors discuss a number of specific areas where they believe new understanding of the CNS from basic science is having a fundamental impact on neurorehabilitation and is leading to new therapeutic approaches. These areas have constituted a basis for development of some basic principle...

Since inception, pathology has served as the indispensable link between basic science and clinical disease, encompassing the defining of disease processes and mechanisms through observation of structural alterations, as well as hypothesis-driven experimentation. The careful study of pathology has delivered an understanding of disease sufficient to guide effective treatment, and recognize ineffe...