Abstract The high melting point and strong chemical bonding of NbB 2 pose a great challenge to the preparation high-density nanostructured composite coating. Herein, we report novel, simple, efficient method fabricate in-situ -NbC-Al O 3 coating by plasma spraying Nb 5 -B 4 C-Al powder, aiming at realizing higher densification ultra-fine microstructure properties were studied comparatively with...

A dense Al-SiCp nanocomposite coating with high volume fraction of nano SiCp reinforcement (60 vol.%) was fabricated through cold spraying deposition milled Al-60SiCp powder in the present paper. Microstructure evolution during ball milling process, microstructure characteristics and hardness sprayed were studied. Al particles underwent fracture deformation SiC evenly distributed soft base mate...

OBJECTIVES The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs). METHODS The moisture content of MCC was optimised using the spray water method and analysed using thermog...

BACKGROUND The objective of this study was to evaluate fluid-bed coating as a new technique to prepare a pellet-based solid self-nanoemulsifying drug delivery system (SNEDDS) using cyclosporin A as a model of a poorly water-soluble drug. METHODS The rationale of this technique was to entrap a Liquid SNEDDS in the matrix of the coating material, polyvinylpyrrolidone K30, by fluid-bed coating. ...

The application of dense gases in particle formation processes has attracted great attention due to documented advantages over conventional technologies. In particular, the use of dense CO₂ in the process has been subject of many works and explored in a variety of different techniques. This article presents a review of the current available techniques in use in particle formation processes, foc...

The aim of our study was to improve the availability of Rofecoxib a practically insoluble non-steroidal anti-inflammatory drug, as a model drug by using liquisolid technique. The effect of powder substrate composition on the flowability and compressibility of liquisolid compacts were evaluated. Specifically, several liquisolid formulations, containing 25-mg Rofecoxib, which containing different...

portant component of the mitochondrial respiratory chain (1). Because of its poor aqueous solubility, Coenzyme Q10 (CoQ10) presents a challenge when developing a formulation for oral administration. Many approaches have been used to improve the in vitro dissolution of CoQ10. Some of the approaches include complexation with cyclodextrins (2), preparation of redispersible dry emulsion (3), solid ...

The aim of present investigation was to develop press coated tablet for pulsatile drug delivery of ketoprofen using hydrophilic and hydrophobic polymers. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of rheumatoid arthritis. The press coated tablets containing ketoprofen in the inner core was formulated with an outer shell by d...

The objective of this study is to get a better understanding of dry powder coating process using experiments and numerical methods. Materials chosen as host particles are SUGLETS® (granules mainly consisting of sugar) and as invited particles, magnesium stearate (MgSt). These two materials are introduced into a high shear mixer (Cyclomix). Operations were performed at various mixing time and ro...