The study was aimed at understanding the nature and pattern of serum lactate, cardiac troponin I changes associated with acute Trypanosoma brucei infection dogs. It also seeks to investigate usefulness these biomarkers in monitoring disease progression predicting mortality. Twenty healthy adult dogs both sexes were used for study. All intra-peritoneally inoculated 1ml phosphate buffered saline ...

The purpose of this study was to investigate the relationship between sodium nitroprusside-induced relaxation, inhibition of the sodium-potassium pump, and cyclic guanosine monophosphate. Exposure of rat thoracic aorta to ouabain, or potassium- or magnesium-free Krebs-Ringer bicarbonate solution, procedures which presumably inhibit the sodium-potassium pump, or to potassium chloride or tetraeth...

The myocardial ischemic border zone is associated with the initiation and sustenance of arrhythmias. The profile of ionic concentrations across the border zone play a significant role in determining cellular electrophysiology and conductivity, yet their spatial-temporal evolution and regulation are not well understood. To investigate the changes in ion concentrations that regulate cellular elec...

We describe a 21 month old male infant who presented with failure to thrive associated with severe hypokalaemia and metabolic acidosis, together with hypomagnesaemia. Evaluation revealed marked renal and probable faecal potassium wasting, distal renal tubular acidosis, mild urinary magnesium wasting, and a normal gastric pH (gastric H(+)-K(+)-ATPase). Hypokalaemic forms of metabolic acidosis, s...

BACKGROUND Metabolic acidosis is a common complication of chronic kidney disease; current guidelines recommend treatment with alkali if bicarbonate levels are lower than 22 mMol/L. In fact, recent studies have shown that an early administration of alkali reduces progression of CKD. The aim of the study is to evaluate the effect of fruit and vegetables to reduce the acid load in CKD. METHODS W...

BACKGROUND The role of aging on the salivary gland function still remains controversial and inconclusive. This study was undertaken to determine the effects of aging on the morphology and secretion of salivary glands using male Wistar rats. METHOD There were three age groups; group A (3 months old; n = 8), group B (6 months old; n = 8), and group C (9 months old; n = 8). Body weights, salivar...

The study was designed to investigate the effect of rifampicin on the kidney biomarkers and histopathology of kidney of albino rats. 42 albino rats were used and rifampicin was administered at 1.10mg/120gBW and 0.55mg/120gBW for intervals of 20, 40 and 60days.Animals were sacrificed 24 hours after the last day of administration and blood samples were collected for the estimation of urea and cre...

The principal components of the gand A-tensor of Cu obtained from single crystal ESR spectra of copper doped KHCO3 are gzz = 2.2347(1), gyy = 2.0474(1), gxx = 2.0468(1), Azz = 20.43(2) mT, Ayy = 3.22(1) mT, Axx = 2.63(2) mT. The unique axes of both tensors are parallel and lie in the mirror plane of the point group of the crystal (2/m). The direction of this axis conforms with the expectation f...

Saliva was collected from the parotid salivary gland of anaesthetized sodium-replete red kangaroos (Macropus rufus) by catheterization of the parotid duct through its opening in the mouth. Salivary secretion was stimulated by ipsilateral intracarotid infusion of acetylcholine at varying rates to produce salivary flow rates ranging from 0.056 +/- 0.0042 (S.E. of mean) to 4.509 +/- 0.1136 ml min-...