This case report describes a 17-year-old boy with sensory strabismus due to keratoconus and an ipsilateral nodular lesion of the bulbar conjunctiva. The aligned eye was the right eye and keratoconus in this eye was of late onset. Vision in the left eye was poor and keratoconus was advanced in this eye. Due to the longstanding nature of the keratoconus and its occurrence in a developmentally sen...

Despite numerous studies, the causes of both development and progression of keratoconus remain elusive. Previous studies of this disorder focused mainly on one or two genetic factors only. However, in the analysis of such complex diseases all potential factors should be taken into consideration. The purpose of this study was a comprehensive analysis of known keratoconus loci to uncover genetic ...

Two-dimensional electrophoretic maps of extracts from eleven normal and eleven keratoconus corneas were compared. Of the eleven corneas analyzed, eight were pooled and the remaining three were analyzed individually. Several differences were demonstrated between electrophoretic patterns of normal and keratoconus corneas. In keratoconus corneas, 1) two abnormal components (MW 54kD and 26kD) were ...

PURPOSE To compare the corneal volume in keratoconic and normal eyes to improve our understanding of the tissue distribution associated with the disease. MATERIALS AND METHOD The Oculus Pentacam tomographer (Oculus Inc., Wetzlar, Germany) was used to analyze the corneal volume contained within discs with diameters of 3, 5, 7, and 10 mm in 21 patients with keratoconus and 21 matched healthy co...

To determine if differences in topographic progression between unaffected keratoconus relatives and normal controls can predict factors associated with the development of keratoconus in a longitudinal study. We recruited 369 unaffected keratoconus relatives and 119 normal controls in Los Angeles. Both eyes of subjects were examined at baseline clinically and by quantitative videokeratography an...

UNLABELLED PURPOSETo review the topographic patterns associated with keratoconus suspects and provide criteria for keratoconus screening. METHODS Case study using maps from the NIDEK OPD-Scan II and OPD Station to highlight patterns seen in keratoconic corneas. RESULTS Five criteria are listed for the detection of keratoconus: 1) apex of the cone is not centered at the 6-o'clock semi-meridi...

PURPOSE To investigate the genetic association between unrelated Korean keratoconus patients and interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and IL1 receptor antagonist (IL1RN) gene polymorphisms. METHODS We investigated the association between IL1A (rs1800587, rs2071376, and rs17561), IL1B (rs1143627, rs16944, rs1143634, and rs1143633), and IL1RN (rs419598, rs423904, rs424078, and...

OBJECTIVE To report the in vivo laser confocal microscopy findings of corneas with keratoconus, with special attention to abnormality of Bowman's layer and sub-Bowman's fibrous structures (Kobayashi-structures [K-structures]). METHODS Sixteen keratoconic eyes in 8 consecutive patients with keratoconus (4 males, 4 females, mean age, 41.1 years) were included in this study. Slit-lamp biomicrosc...

Keratoconus is a corneal disorder progressive characterized by thinning and steepening of the central and paracentral cornea, which leads to protrusion [1]. The exact cause of the disease remains to be fully elucidated although its etiology probably is multifactorial with a genetic predisposition to keratoconus influenced by external environmental factors (eye rubbing and atopy) [2] with differ...

Keratoconus is a noninflammatory, usually, bilateral progressive disease. It is a pathology characterized by a progressive thinning and ectasia of the stroma that results in cone-shaped cornea. In advanced keratoconus with corneal opacities, keratoplasty, can be the only surgical alternative for a long time. Recently, new treatment alternatives were developed in keratoconus treatment, such as i...