PURPOSE OF REVIEW To outline the most urgent challenges in the management of advanced melanoma. RECENT FINDINGS Considerable progress in targeted and immunotherapy of advanced melanoma has opened a perspective for a cure if all molecular and medical information is integrated in a rational precision treatment algorithm. SUMMARY Bioinformatics and system biology approaches will be needed to d...

The current research investigated the associations among dimensions of perfectionism, unconditional self-acceptance, and self-reported depression. A sample of 94 students completed the Multidimensional Perfectionism Scale, the Unconditional Self-Acceptance Questionnaire, and a selfreport depression measure. Correlational results indicated that all three trait dimensions of perfectionism (i.e., ...

Consider the sequence of poles A = {α1, α2, . . .}, and suppose the rational functions φn with poles inA form an orthonormal system with respect to an Hermitian positive-definite inner product. Further, assume the φn satisfy a three-term recurrence relation. Let the rational function φ n\1 with poles in {α2, α3, . . .} represent the associated rational function of φn of order 1; i.e. the φ n\1 ...

Consider the sequence of polesA = {α1, α2, . . .}, and suppose the rational functions φj with poles in A form an orthonormal system with respect to a Hermitian positive-definite inner product. Further, assume the φj satisfy a three-term recurrence relation. Let the rational function φ j\1 with poles in {α2, α3, . . .} represent the associated rational function of φj of order 1; i.e. the φ (1) j...

Despite their apparent simplicity, Web applications are surprisingly difficult to develop, if our aim is to build applications that behave correctly under regular conditions as well as adverse circumstances like out-of-order requests and race conditions. In this paper, we describe our experiences deriving customer-oriented acceptance tests for Web applications by modeling the essential capabili...

Conflicting with the law will make them feel a lot of pressure and psychological changes like shame, regret, unable to accept themselves. If they have positive thinking, easily their condition. This study aimed observe effect thinking training in improving self-acceptance juveniles who were undergoing period correctional program. The subjects this included 24 at Class I Juvenile Correctional Fa...

the goal of this study was to assess attitude towards plagiarism in faculty members of medical school at tehran university of medical sciences. one hundred and twenty medical faculty members of tehran university of medical sciences were enrolled in this cross-sectional study. they were asked to answer to valid and reliable persian version of attitude towards plagiarism questionnaire. attitude t...

Individuals differ in the degree to which they tend to habitually accept their emotions and thoughts without judging them-a process here referred to as habitual acceptance. Acceptance has been linked with greater psychological health, which we propose may be due to the role acceptance plays in negative emotional responses to stressors: acceptance helps keep individuals from reacting to-and thus...