THE most well-known types of hormone-dependent tumours are those of breast, endometrium and prostate, but several other types probably exist (Crowley, 1969; Crowley & Duwe, 1969). Because of their special nature they are open to endocrine manipulation in ways not possible in other tumours. Tumours of the ovary are not easily characterized in this respect as there are so many types and several a...

Background: Endometriosis is a gynecological disease associated with severe pelvic pain and infertility. Immunological changes that occur in patients with endometriosis include reduced natural killer cell and T-lymphocyte cytotoxicity in the peritoneal fluid, and an elevated number of activated macrophages. MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation an...

OBJECTIVE To determine if power Doppler ultrasound examination of the endometrium can contribute to a correct diagnosis of endometrial malignancy in women with postmenopausal bleeding and endometrium > or = 5 mm. METHODS Eighty-three women with postmenopausal bleeding and endometrium > or = 5 mm underwent gray-scale and power Doppler ultrasound examination using predetermined, standardized se...

BACKGROUND Matrix metalloproteinases (MMPs) and their inhibitors are key-players in extracellular matrix and basement membrane degradation, and are involved in both physiological and malignant processes. The aim of this study was to examine MMP-2, -7 and -9 and TIMP-1 and -2 expression in normal, hyperplastic and malignant endometrium, and their relation to clinical and histological prognostic ...

During embryo implantation in pigs, the uterine endometrium undergoes dramatic morphological and functional changes accompanied with dynamic gene expression. Since the greatest amount of embryonic losses occur during this period, it is essential to understand the expression and function of genes in the uterine endometrium. Although many reports have studied gene expression in the uterine endome...

background: there is a fundamental correlation between follicles and endometrium in intracytoplasmic sperm injection (icsi) cycles. objective: to assess the relation between perifollicular perfusion and sub endometrial parameters in doppler ultrasonography and outcome of in icsi cycles. materials and methods: in this prospective deh1ive pilot study 10 patients were enrolled. strict inclusion cr...

background: acceptance of uterus and reaction between endometrium and embryo has an important role for implantation. muc1 an integral membrane mucin is expressed on the apical surface of uterine epithelial cells and could have effects on its receptivity. objective: the aim of this study was to evaluate the changes in muc1 expression of gravid mouse endometrium with and without hyperstimulation ...

Abstract The objective of this study was to evaluate transcriptomic differences in reproductive tissues beef heifers with high vs. low PAG concentrations carrying viable pregnancies during the attachment and early placentation periods. Bos indicus (n=25) were subjected embryo transfer on day 7 IVP embryos, confirmed at slaughter. Heifers harvested days 25 (n=8) 36 (n=8), samples from endometriu...

To the editor: Hereditary portion and genetic status are very important to work out strategies for cancer prevention and early detection in gynecologic cancers. Familial history of related cancers within the second degree relatives are approximately 10% and 20% in endometrial cancer and ovarian cancer, respectively [1,2]. The proportion of genetic background and germline mutation in Korean wome...