Lipemic plasma from normal and hyperlipemic patients has been fractionated on columns of 3% (w/v) aqueous polyvinylpyrrolidone (PVP) and the lipid composition of the separated fat particles (S(f) > 400) measured. Plasma from patients with carbohydrate-induced lipemia on fat-free diets contained particles with a greater percentage of cholesterol and phospholipid than either normal primary partic...

OBJECTIVE To evaluate the role of hyaluronic acid (HA) for sperm selection before intracytoplasmic sperm injection (ICSI). DESIGN Three prospective studies. SETTING Private assisted reproduction center in Italy. PATIENT(S) Study 1: 20 men. Study 2: 15 men. Study 3: 206 couples treated with ICSI on a limited number of oocytes per patient (1-3) in accordance with Italian IVF law. INTERVEN...

While hot melt extrusion is now established within the pharmaceutical industry, the prediction of miscibility, processability and structural stability remains a pertinent issue, including the issue of whether molecular interaction is necessary for suitable performance. Here we integrate the use of theoretical and experimental drug-polymer interaction assessment with determination of processabil...

The silver nanoparticles (AgNPs) have been applied as an antibacterial agent in consumer products, cosmetics, and food industries. In this present work, AgNPs were synthesized various mediums of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), chitosan using the pulse laser ablation synthesis method. Experimentally, a Nd:YAG beam (1064 nm, 7 ns, 30 mJ) was directed mirror focused quartz l...

Methods of preparation and application of amorphous form are well established but it is equally important to note that devitrification of amorphous drugs has limited their applications. Present study was performed to investigate mechanism for amorphous drug stabilization using Gelucire in comparison with polyvinylpyrrolidone (PVP). Etoricoxib and celecoxib were taken as model drugs for this stu...

Although polymeric membranes are widely used in the purification of protein pharmaceuticals, interactions between biomolecules and membrane surfaces can lead to reduced membrane performance and damage to the product. In this study, single-molecule fluorescence microscopy provided direct observation of bovine serum albumin (BSA) and human monoclonal antibody (IgG) dynamics at the interface betwe...

With the goal to better process monitoring of occurring fouling, a backscatter probe was developed perform in-line measurements in half-shell reactor during reaction N-vinylpyrrolidone (NVP) polyvinylpyrrolidone (PVP). The measurement technique detects changes bands UV range, which allows direct correlation with concentration. Thus, measured absorbance signal conclusion on accumulation fouling ...

BACKGROUND Photosensitizer based fluorescence imaging and spectroscopy is fast becoming a promising approach for cancer detection. The purpose of this study was to examine the use of the photosensitizer chlorin e6 (Ce6) formulated in polyvinylpyrrolidone (PVP) as a potential exogenous fluorophore for fluorescence imaging and spectroscopic detection of human cancer tissue xenografted in preclini...

In this study a solid dispersion and a physical mixture of cilazapril (CIL) with a biopolymer - polyvinylpyrrolidone (PVP) as a carrier were prepared so as to investigate the effect of PVP on the stability of CIL. CIL is unstable in solid state and decomposes rapidly under humid conditions. It requires stabilization to ensure safety of its use. The studied CIL/PVP formulations were prepared by ...

In this study a solid dispersion and a physical mixture of cilazapril (CIL) with a biopolymer - polyvinylpyrrolidone (PVP) as a carrier were prepared so as to investigate the effect of PVP on the stability of CIL. CIL is unstable in solid state and decomposes rapidly under humid conditions. It requires stabilization to ensure safety of its use. The studied CIL/PVP formulations were prepared by ...