There is a definitive association between valproate therapy and acute pancreatitis. More than 50 cases have been reported. Most of the reported cases were mild yet there were a few more cases with higher morbidity and mortality. The risk is higher in patients under 20 years of age, during the first year of therapy, on the patient having encephalopathy or chronic renal failure and on patients wi...

Mechanisms responsible for the attention impairment in epileptics may be different from those involved in isolated AttentionDeficit-Hyperactivity Disorder (ADHD) [1]. Often a combination of anti-epileptic drugs (AEDs) used in combinations are required for intractable epilepsy, but this can also exacerbate drug-induced side effects such as slowed cognition and sedation [2]. Symptoms of inattenti...

Antiepileptic drugs (AED) alter neuronal excitation levels and may result in neurocognitive changes. In recent years several new AEDs have been introduced which additionally are used to treat mood disorders, neuropathic pain, and migraine. Generally, very few controlled trials have systematically examined the neurocognitive side effects of AEDs. In particular, polytherapy with the newer AEDs is...

Epilepsy is one of the most common neurological problems affecting approximately 1% of the world's population with higher incidence among elderly individuals. Although depression is a common comorbid condition in patients with epilepsy, there is a paucity of information regarding depression in geriatric patients with epilepsy. This study analysed a group of 83 patients affected by different epi...

OBJECTIVE Duloxetine, a selective serotonin and norepinephrine reuptake inhibitor (SNRI), is currently approved in many countries for the treatment of Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD). The present naturalistic study was aimed to investigate tolerability of Duloxetine in a sample of patients with affective disorders and psychiatric/medical comorbidity, compa...