Aneuploidy is a hallmark of human cancers originating from abnormal mitoses. Many aneuploid cancer cells also have greater-than-diploid DNA content, suggesting that polyploidy is a common precursor to aneuploidy during tumor progression. Polyploid cells can originate from cell fusion, endoreplication, and cytokinesis failure. Recently we found that cell cannibalism by entosis, a form of cell en...

Polyploidy, resulting from whole genome duplication, is a widespread phenomenon throughout Eukaryotic kingdoms. It estimated that 15% of speciation events in plants due to polyploidization and 16% plant species encompass ploidy variation. In spite the evolutionary economic significance polyploidy, there limited set tools would allow routine population genetic genomic analysis polyploid systems,...