OBJECTIVES We have assessed the kinetics of drug release in relation to the full or partial hydration and swelling of matrices under standard and modified United States Pharmacopeia (USP) apparatus II using a novel index, defined as the symmetrical shape factor. The symmetrical shape factor describes the regularity of the hydration rate of the matrix perimeter relative to its central regions. ...

Despite the tremendous advancement in drug delivery, oral route remains the preferred route for the administration due to higher levels of patient compliance. But conventional forms offer no control over drug delivery, leading to fluctuations in plasma drug level. These have a disadvantage of a release all or nothing emptying process while the multiple unit particulate system pass through the g...

We addressed the effect of implant thickness, implant porosity, and polyurethane (PU) chemistry on angiogenesis and on the foreign body response in rats. The following materials were implanted subcutaneously for 7 weeks then excised for histologic analysis: a solid PU; a solid polyurethane with silicone and polyethylene oxide (PU-S-PEO); porous expanded polytetrafluoroethylene (ePTFE); and poro...

The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanoparticles were pure iron oxide having spherical shape with the average diameter of 9 nm, compared wit...

High molecular weight linear polyethylene, in the form of 7 nm thin single-lamella nanocrystals with a diameter of up to 200 nm, is generated via aqueous catalytic polymerization using the water-soluble catalyst precursor [κN,O-{2,6-(3′,5′-(F3C)2C6H3)2C6H3-NC(H)-(3,5-I2-2-OC6H2)}NiCH3{P(3-C6H4SO3Na)3}] (1-TPPTS). Studies under true pressure reactor conditions using a C-labeled catalyst precurs...

Polyethylene oxide-based muco-adhesive buccal films containing adipic acid active pharmaceutical ingredient (API) and xylitol were developed using hot-melt extrusion (HME) coupled with Fused Deposition Modeling (FDM) three-dimensional (3D) printing. The immediate release mucoadhesive are intended for treatment or amelioration of xerostomia (dry mouth condition). Different formulae as the main s...

In this work, polymer composite materials based on linear low-density polyethylene and nanoparticles of copper oxide were characterized in view their physical mechanical properties. Various concentrations nanosized CuO filler tested. It was found, that properties resulting depend the concentration. Mechanical parameters studied static dynamical regimes as well temperature dependence dynamic beh...