Pyrrole-imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture. Gene regulation by polyamides requires efficient cellular uptake and nuclear localization properties for candidate compounds. To further optimize Py-Im polyamides for enhanced potency in cell culture, a focused...

Nanocomposites were synthesized from reactive thermally stable montmorillonite and aromatic-aliphatic polyamide obtained from 4-aminophenyl sulfone and sebacoyl chloride. Carbonyl chloride terminal chain ends were generated using 1% extra sebacoyl chloride that could interact chemically with the organoclay. The distribution of clay in the nanocomposites was investigated by XRD, SEM, and TEM. Me...

This paper presents initial development of polymer nanocomposites (PNC) material for rapid manufacturing (RM) application. PNC materials containing a polyamide (PA) and nano particles (5wt%) were produced by solution blending with the aim to improve the mechanical properties. Commercial polyamide 6 (PA6) was dissolved in formic acid (HCO2H) together with two different types of nano particle mat...

The "RapidTool" Short Run (SR) Tooling Process using the Copper Polyamide material provides a route to mold inserts for injection molding made directly in the Selective Laser Sintering machine. The STL files for the mold inserts are shelled and conformal cooling lines and ejector pin guides are added before SLS processing. Sintering of the material in the SLS machine provides quick metal/plasti...

Hairpin polyamide-chlorambucil conjugates containing an alpha-diaminobutyric acid (alpha-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized gamma-DABA turn. Although the DNA-binding properties of unconjugated polyamides are similar, the alpha-DABA conjugates display increased alkylation specificity and decreased rate of reaction. Treatment of a huma...

the main objective of the present work was to synthesis polyamide 6 through anionic polymerization of ε-caprolactam in an internal mixer. the reaction time and the rheological properties of samples during the polymerization were studied. the samples were characterized by thermo gravimetry analysis (tga), differential scanning calorimeter (dsc) and ft-ir spectrometer. the melt flow behavior and ...

practical applications of conducting polymers such as polyaniline as membranes are particulary limitedbecause of their poor mechanical properties. however by mixing polyaniline with some conventional insulatingpolymers such as nylon and preparation composite films through solvent casting or blending, it seems to be asuitable way in order to increase the mechanical properties of the conducting p...