Temperature-sensitive hyaluronic acid (HA) hydrogels were synthesized by photopolymerization of vinyl group modified HA in combination with acrylate group end-capped poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer (Pluronic F127). The synthesized HA/Pluronic composite hydrogels gradually collapsed with increasing temperature over the range of 5-40 degrees ...

AMA Islami S, Rahmayanti F, Astuti A. Awareness and knowledge of the effects smoking on oral health, cessation motivation among high school students in Jakarta. Journal Stomatology. 2023;76(2):123-127. doi:10.5114/jos.2023.128817. APA Islami, S., Rahmayanti, F., & Astuti, (2023). Stomatology, 76(2), 123-127. https://doi.org/10.5114/jos.2023.128817 Chicago Shera Cynthia, Febrina Ambar Kusuma Ast...

Polyethylenimine (PEI) is considered to be a promising non-viral gene delivery vector. To solve the toxicity versus efficacy and tumor-targeting challenges of PEI used as gene delivery vector, we constructed a novel non-viral vector DR5-TAT-modified Pluronic-PEI (Pluronic-PEI-DR5-TAT), which was based on the attachment of low-molecular-weight polyethylenimine (LMW-PEI) to the amphiphilic polyme...

Pluronic/bile salt/phospholipid mixed micelles (Pluronic/BS/PS-MM) drug carrier system for solubilization hydrophobic drugs was developed. A typical hydrophobic compound, pyrene, was selected as a representative hydrophobic compound to model the hydrophobic drugs. Five Pluronics, F68, F88, F98, F108, and F127 with different PPO chain length were studied. CMC data and solubilization capacities w...

This article provides a brief and basic discussion of Pluronic lecithin organogel to include its history, its components, its mechanism of action, the range of active pharmacological agents that can and cannot be incorporated into a Pluronic lecithin organogel, as well as important information for those pharmacists who compound Pluronic lecithin organogel.

Although the effects of red blood cell (RBC) aggregation on low-shear rate blood viscosity are well known, the effects on in vivo flow resistance are still not fully resolved. The present study was designed to explore the in vivo effects of RBC aggregation on flow resistance using a novel technique to enhance aggregation: cells are covalently coated with a block copolymer (Pluronic F-98) and th...

Chemotherapy is one of the most conventionally used therapeutic interventions for treating various diseases. Chances of acquiring multidrug resistance in response to chemotherapeutic agents are exceedingly common among patients. Drug resistance arises mainly due to overexpression of efflux transporters such as P-glycoprotein and multidrug resistance-associated protein of the ATP-binding cassett...

PROTEINS THAT PROMOTE NEURITE OUTGROWTH ............................................................ 119 Soh~ble Neurotrophic Agents .................................................................................... 122 ECM Proteins .......................................................................................................... 123 CAMs .................................................

Poloxamer block copolymers have been studied in multiple applications as drug delivery systems (DDS). These A-B-A amphiphilic block copolymers up-regulate the expression of selected genes in cells and alter genetic responses to antineoplastic agents in cancer. One example is poloxamer 188, also known as pluronic F68, which may be promising as a carrier in DDS. To clarify the possible mechanisti...