Oxidative stress is caused by superoxide anion or hydrogen peroxide under aerobic growth condition. Some bacteria could eliminate toxic species of oxygen using S o d A enzyme. The effect of superoxide generating chemicals and hydrogen peroxide on sodA and f l p A promoter activities were investigated in this study. The observation indicated that the f l p A promoter activity increased with mena...

Benjakul have also been used for cancer therapy by folk medicine. The ethanolic extracts, five fractions and three pure compounds from Benjakul were investigated for cytotoxic activities against two types of human lung cancer cell lines (COR-L23 and A549) and one normal human lung myofibroblasts (MRC-5). The cytotoxic activities of the BEN-3 fraction which fractionated with vacuum liquid chroma...

Lung cancer is currently the commonest malignancy and the leading cause of cancer-related death in the world (Jemal et al., 2009). Non-small cell lung cancer (NSCLC) represents about 80% of primary lung cancer cases and approximately two thirds of these patients are diagnosed at an advanced stage (Jemal et al., 2009). Although several effective chemotherapeutic agents are administrated, the pla...

Three naphthoquinone derivatives (plumbagin, juglone, and menadione) have been reported with antibacterial, antifungal, and antiviral properties and could potentially be used as anticancer agents because they can provoke apoptosis. However, they are also strong oxidants and cause cytotoxicity and even necrosis, so they are only limited to experimental chemotherapeutic use. In order to understan...

Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent ...