Plasmepsin IV (Plm IV) is one of the aspartic proteases present in the food vacuole of the malaria parasite Plasmodium falciparum involved in host hemoglobin degradation by the parasite. Using a series of previously synthesized plasmepsin inhibitors [Ersmark, K., et al. (2005) J. Med. Chem. 48, 6090-106], we report here experimental data and theoretical analysis of their inhibitory activity tow...

Today, in order to confront the growing complexity of products and organisations, Aeronautic, Space and Defence (ASD) manufacturing enterprises are using more and more System Engineering, Product Lifecycle Management and Computer Aided Solutions for various engineering and management activities. Combined with a more and more important outsourcing, such trends led to the emergence of what is cal...

Numerous studies have suggested a substantial genetic contribution in the etiology of the primary form of restless legs syndrome (RLS) and periodic leg movements (PLM). We describe the symptoms, the sleep profiles and physiological parameters of two families in which several members present RLS/PLM. The proband of family 1 is a 70-year-old woman and the proband of family 2 is a 57-year-old woma...

This paper reviews the perennial problem of knowledge management / information integration in large scale, complex and knowledge intensive organisations such as automotive industries. Automotive industry is under increased pressure to produce low cost customised products using innovative agile manufacturing techniques. Presently this innovation has focused on the improved process development be...

In this dissertation we studied asymptotic properties of shrinkage estimators, and compared their performance with absolute penalty estimators (APE) in linear and partially linear models (PLM). A robust shrinkage M-estimator is proposed for PLM, and asymptotic properties are investigated, both analytically and through simulation studies. In Chapter 2, we compared the performance of shrinkage an...

PLM is universally recognized as a valid strategy to reduce time to market, increase process efficiency and reduce lifecycle cost. Despite the importance for industry to prove these emphasized competitive advantages, PLM achievable benefits still remain intangible. Their measurement is particularly difficult in case of networked enterprises where each of them is characterized by different organ...

OBJECTIVES To detect changes in the collagen fibril network in articular cartilage in a canine experimental model of early osteoarthritis (OA) using microscopic magnetic resonance imaging (microMRI) and polarised light microscopy (PLM). METHODS Eighteen specimens from three pairs of the medial tibia of an anterior cruciate ligament transection canine model were subjected to microMRI and PLM s...

This paper presents a knowledge management experiment carried out in an industrial company. Our research concerns the development of a knowledge engineering module integrated in a PLM system which is based on a multi-domain scheme (project, product, process and use) taking into consideration several viewpoints (structural, functional, dynamic, etc.). This PLM system enables us to capture techni...

Companies that collaborate within the product development processes need to implement an effective management of their collaborative activities. Despite the implementation of a PLM system, the collaborative activities are not efficient as it might be expected. This paper presents an analysis of the problems related to the collaborative work using a PLM system. From this analysis, we propose an ...

Betriebliche Informationssysteme zum Produktlebenszyklusmanagement (PLM) dienen in den Unternehmen der Integration von technischer und betriebswirtschaftlicher Informationsverarbeitung. Ihnen kommt eine besondere Bedeutung für die produktbezogene Kostenschätzung im Angebotsengineering und tendenziell für das Lebenszykluskostenmanagement zu. Im vorliegenden Beitrag wird diese zentrale Rolle von ...