the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...

A recent trend in the design of distributed applications is to systematically separate their platform-independent and platform-specific aspects, by describing them in separate models. The main benefits of this approach stem from the possibility to derive different platform-specific models (PSMs) from the same platform-independent model (PIM), and to partially automate the model transformation p...

The model-driven software development for hard real-time systems promotes the usage of the platform independent model as major design artifact. It is used to develop the software logic at a high level of abstraction and enables analysis like for example model checking of critical model properties. Ideally, starting with the platform independent model, the platform specific model serves only as ...

Model Driven Architecture (MDA) defined by Object Management Group (OMG) in 2000 promotes the model engineering in order to facilitate code production in a cost-effective manner. It advocates the distinction between models designed independently of any technical consideration of the underlying platform (the Platform Independent Model – PIM) and models that include such considerations (the Platf...

M odel-driven software product lines (MD-SPLs) are created from domain models w hich are transformed, merged and composed w ith reusable core assets, until software products are produced. Model transformation chains (MTCs) must be specified to generate such M D-SPLs. This paper presents a framew ork for creating platform-independent M D-SPLs; such framew ork includes a domain specific language ...

ModelA model containing common features of several models whileignoring their differences. Abstract PlatformA platform that addresses common techniques, technologiesand patterns that exist within several platforms while ignoringtheir differences.PlatformA platform that addresses common techniques, technologiesand patterns that exist within several platforms while ign...

Programming models for cloud computing has become a research focus recently. Cloud computing promises to provide on-demand and flexible IT services, which goes beyond traditional programming models and calls for new ones. Some progress has been made in cloud computing programming models for large-scale data processing, but little was done on models of predictable performance. With the advantage...

Model-driven tools frequently rely on advanced technologies to support model queries, view maintenance, design rule validation, model transformations or design space exploration. Some of these features are initiated explicitly by domain engineers (batch execution) while others are executed automatically when certain trigger events are detected (live execution). Unfortunately, their integration ...