Different approaches to enhance healing of hard or soft tissues include the use cytokines and growth factors modify cellular behaviour. Numerous are found in autologous blood concentrates - platelet-rich plasma (PRP) fibrin (PRF). Enamel matrix derivative (EMD) may improve tissue via amelogenins. Bilayered collagen (CM) is used for augmentation. The aim present study was assess potential benefi...

Platelets are known primarily for their role in hemostasis, but there is increasing interest in the effect of platelets on wound healing. Platelet isolates such as platelet-rich plasma have been advocated to enhance and accelerate wound healing. This article describes the use of a novel preparation, platelet-rich fibrin matrix (PRFM), for facial plastic surgery applications such as volume augme...

BACKGROUND Platelet-rich fibrin (PRF), a platelet-rich plasma (PRP) derivative mainly composed of fibrin networks, has been increasingly demonstrated to be effective in wound healing in clinical and pre-clinical animal studies. However, there has still been a concern that major growth factors may significantly be loss from PRF during its preparation through the slow clotting process. To address...

Platelet-Rich Fibrin (PRF) was first described by Choukroun et al., (2001). It has been referred to as a second-generation platelet concentrate, which has been shown to have several advantages over traditionally prepared platelet-rich plasma. PRF has a physiologic architecture that is very favourable to the healing process, obtained due to the slow polymerization process. The development of pla...

Introduction: Clinicians tend to encounter unfavorable situations in the treatment of teeth with severe attachment loss. Periodontal regeneration has been a successful therapeutic approach treatments that require long-term prognosis improvement. This case shows benefits combined regenerative periodontal therapy patient molar severely compromised by furcation, intrabony defects and loss apex. Ca...

We have previously postulated that surface membrane proteins become specifically associated with the internal platelet cytoskeleton upon platelet activation (Tuszynski, G.P., Walsh, P.N., Piperno, J., and Koshy, A. (1982) J. Biol. Chem. 257, 4557-4563). Four lines of evidence are in support of this general hypothesis since we now show that platelet surface receptors for fibrin become specifical...

A method to produce platelet-rich plasma and platelet concentrate using a double centrifuge technique in combination with the fibrin adhesive Tisseel is described. This technique constitutes the basic mixture for augmenting and improving an inadequate bone site. Also described is a procedure by which autologous bone or bone substitute is added to this mixture to increase the volume of grafting ...

Concentrated growth factors are extracted from platelet-rich plasma obtained healthy adult veins by physical gradient centrifugation, and the activated platelets release various cytokines, which can be further converted into concentrated liquid or gel preparations different centrifuge tubes. These widely used in clinical treatments fields, such as dentistry, dermatology surgery. In this article...