von Willebrand disease (vWD) is a bleeding disorder caused by quantitative (type 1 and 3) or qualitative (type 2) defects of von Willebrand factor (vWF). The molecular basis of type 2 and 3 vWD are now known and those of type 1 vWD are being understood. Phenotypic diagnosis is based on the measurements of plasma and platelet vWF, of the ability of vWF to interact with platelet receptors and the...

BACKGROUND Therapeutic success of platelet-rich plasma (PRP) may vary based on the composition and preparation method. The objective of this study was to evaluate the cellular components of platelet concentrates produced by a leucocyte-rich (LR-PRP) and a leucocyte-poor PRP systems (LP-PRP). METHODS Parameters evaluated included platelet recovery, platelet concentration, red blood cell (RBC) ...

Background and objectives. Platelet concentrates for surgical use were often tested as surgical adjuvants in the literature, as a source of platelet growth factors to stimulate healing. Many products are often regrouped under the generic and inaccurate term of Platelet-Rich Plasma (PRP). However, what is tested in many studies is usually a combination of platelets and leukocytes (accurately ter...

BACKGROUND AND OBJECTIVES Storage lesions may prevent transfused platelets to respond to agonists and arrest bleeding. The aim of this study was to evaluate and quantify the capacity of platelet activation during storage using flow cytometry and new markers of platelet activation. MATERIALS AND METHODS Activation responses of platelets prepared by apheresis were measured on days 1, 5, 7 and 1...