نتایج جستجو برای: plasticity reelin

تعداد نتایج: 58657  

Journal: :Development 2005
Mireille Rossel Karine Loulier Christian Feuillet Serge Alonso Patrick Carroll

The cytoarchitecture of the hindbrain results from precise and co-ordinated sequences of neuronal migrations. Here, we show that reelin, an extracellular matrix protein involved in neuronal migration during CNS development, is necessary for an early, specific step in the migration of several hindbrain nuclei. We identified two cell populations not previously known to be affected in reeler mutan...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Amaya Miquelajáuregui Alfredo Varela-Echavarría M Laura Ceci Fernando García-Moreno Itzel Ricaño Kimmi Hoang Daniela Frade-Pérez Carlos Portera-Cailliau Elisa Tamariz Juan A De Carlos Heiner Westphal Yangu Zhao

Cajal-Retzius (C-R) cells play important roles in the lamination of the mammalian cortex via reelin secretion. The genetic mechanisms underlying the development of these neurons have just begun to be unraveled. Here, we show that two closely related LIM-homeobox genes Lhx1 and Lhx5 are expressed in reelin+ cells in various regions in the mouse telencephalon at or adjacent to sites where the C-R...

Journal: :Development 2002
Tara M Herrick Jonathan A Cooper

The disabled 1 (Dab1) p80 protein is essential for reelin signaling during brain development. p80 has an N-terminal domain for association with reelin receptors, followed by reelin-dependent tyrosine phosphorylation sites and about 310 C-terminal residues of unknown function. We have generated mutant mice that express only a natural splice form of Dab1, p45, that lacks the C-terminal region of ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Mirjam Sibbe Eckart Förster Onur Basak Verdon Taylor Michael Frotscher

The development of the hippocampal dentate gyrus is a complex process in which several signaling pathways are involved and likely interact with each other. The extracellular matrix molecule Reelin is necessary both for normal development of the dentate gyrus radial glia and neuronal migration. In Reelin-deficient Reeler mice, the hippocampal radial glial scaffold fails to form, and granule cell...

Journal: :Molecular and cellular biology 2007
Yves Jossin André M Goffinet

Reelin is an extracellular matrix protein with various functions during development and in the mature brain. It activates different signaling cascades in target cells, one of which is the phosphatidylinositol 3-kinase (PI3K) pathway, which we investigated further using pathway inhibitors and in vitro brain slice and neuronal cultures. We show that the mTor (mammalian target of rapamycin)-S6K1 (...

Journal: :Cellular signalling 2011
Zhihua Gao Roseline Godbout

The Reelin-Disabled 1 (Dab1) signaling pathway plays an important role in neuronal cell migration during brain development. Dab1, an intracellular adapter protein which is tyrosine phosphorylated upon Reelin stimulation, has been directly implicated in the transmission and termination of Reelin-mediated signaling. Two main forms of Dab1 have been identified in the developing chick retina, an ea...

Journal: :Molecular and cellular biology 2003
Lionel Arnaud Bryan A Ballif Jonathan A Cooper

Disabled-1 (Dab1) is a cytoplasmic adaptor protein that regulates neuronal migrations during mammalian brain development. Dab1 function in vivo depends on tyrosine phosphorylation, which is stimulated by extracellular Reelin and requires Src family kinases. Reelin signaling also negatively regulates Dab1 protein levels in vivo, and reduced Dab1 levels may be part of the mechanism that regulates...

2013
Tina Notter Irene Knuesel

BACKGROUND Reelin and its downstream signaling members are important modulators of actin and microtubule cytoskeleton dynamics, a fundamental prerequisite for proper neurodevelopment and adult neuronal functions. Reductions in Reelin levels have been suggested to contribute to Alzheimer's disease (AD) pathophysiology. We have previously reported an age-related reduction in Reelin levels and its...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Yves Jossin Masuhara Ogawa Christine Metin Fadel Tissir André M Goffinet

During development, most cortical neurons migrate to the cortical plate (CP) radially. CP development is abnormal in reeler and other mutant mice with defective Reelin signaling. Reelin is secreted by Cajal-Retzius cells and binds to the very low density lipoprotein receptor and apolipoprotein E receptor type 2 receptors on the surface of CP cells, inducing tyrosine phosphorylation of the intra...

Journal: :Neuron 2008
Kazue Hashimoto-Torii Masaaki Torii Matthew R. Sarkisian Christopher M. Bartley Jie Shen Freddy Radtke Thomas Gridley Nenad Šestan Pasko Rakic

Neuronal migration is a fundamental component of brain development whose failure is associated with various neurological and psychiatric disorders. Reelin is essential for the stereotypical inside-out sequential lamination of the neocortex, but the molecular mechanisms of its action still remain unclear. Here we show that regulation of Notch activity plays an important part in Reelin-signal-dep...

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