background: pre-eclampsia (pe) is one of the most important and life-threatening pregnancy disorders that affect at least 3-5% of all pregnancies. imbalance in helper t cell functions may play a role in predisposing to pe or severity of the disease. elevated frequencies of th17 cells in the peripheral blood of pe patients have been reported. several single nucleotide polymorphisms (snp) within ...

Background/objective: Studies of the decidual leukocyte populations in women suffering from spontaneous early pregnancy loss may provide insight into immunpathological aspects and even cast light on the etiology of recurrent spontaneous abortion.Methods: In order to clarify the immunological role of endometrial leukocytes in repetitive abortion of unknown etiology, a comparative analysis of phe...

The effect of 5-bromo-2'-deoxyuridine (BrdUrd) and dibutyryl cyclic AMP (Bt2cAMP) on the expression of the placental isoenzyme of human alkaline phosphatase was examined in BeWo choriocarcinoma cells. By using a combination of specific immunoprecipitation and polyacrylamide-gel electrophoresis of cells labelled either metabolically with [35S]methionine or cell-surface-labelled with 125I, both B...

Medium conditioned by human placental tissue was found to stimulate granulocytic and monocytic colony formation by human marrow cells in semisolid agar cultures. The colony-stimulating activity of unfractionated conditioned medium was equivalent to the activity of standard peripheral blood underlayers. Placentas were a reliable source of active material, and one placenta provided enough materia...

Evidence for extra-hypothalamic expression of kisspeptinergic system is emerging. The present study documents the imuunolocalization kisspeptin and its receptor in placentome buffalo. Gravid uterus was collected from abattoir gestational age estimated by crown-rump length fetus. A section containing caruncle cotyledon used immunohistochemistry. Kp evident feto-maternal junctions with prominent ...

Vasculogenesis and the subsequent step, angiogenesis, are the most important stages for the continuity of placental development. Vasodilator-stimulated phosphoprotein (VASP) has a widespread role in the control of cell motility and participates in filamentous actin formation. We hypothesized that VASP participates in vasculogenesis and angiogenesis, by regulating endothelial cell migration. We ...

Distal-less 3 (Dlx3) is a homeobox factor that functions as a placental-specific transcriptional regulator. Dlx3 null mice (-/-) have compromised placental development and do not survive in utero past embryonic day (E) 9.5. The current studies were undertaken to examine the expression of Dlx3 in mouse placenta during gestation, and to determine whether Dlx3 was involved in placental progesteron...

Abstract Placental malaria can have severe consequences for both mother and child effective vaccines are lacking. Parasite-infected red blood cells sequester in the placenta through interaction between parasite-expressed protein VAR2CSA glycosaminoglycan chondroitin sulfate A (CS) abundantly present intervillous space. Here, we report cryo-EM structures of ectodomain at up to 3.1 Å resolution r...

Abnormal fetal growth, which is associated with both perinatal morbidity as well as metabolic diseases in adulthood, is an important clinical problem affecting as many as 15% of all pregnancies. However, to this date, there is no specific treatment of this condition. Fetal growth is intimately linked to the nutrient transport functions of the placenta and placental amino acid transporter activi...

BACKGROUND Malaria during pregnancy is the main cause of low birth weight (LBW) in the tropics. There are few studies concerning B and T lymphocyte infiltrates in placental malaria infections or their potential association with LBW babies. METHODS A case-control study was conducted at the Medani Hospital, Central Sudan. Cases were women who had LBW deliveries (infants weighed < 2,500 g) and c...