Chronic breathlessness, a persistent and disabling symptom despite optimal treatment of underlying causes, is frightening with serious widespread impact on patients their carers. Clinical guidelines support the use morphine for relief chronic breathlessness in common long-term conditions, but questions remain around clinical effectiveness, safety longer-term (>7 days) administration. This tr...

Generalized pustular psoriasis is a potentially life-threatening neutrophilic skin disease characterized by recurrent flares of widespread erythema and eruption sterile pustules. In the Effisayil™ 1 study (NCT03782792), 53 patients with generalized flare were treated placebo or spesolimab, humanized anti-interleukin-36 receptor monoclonal antibody, first targeted treatment to be studied in rand...

Background: Probiotic potential (efficacy and safety) of Bacillus coagulans SNZ 1969 has been studied in patients with constipation-predominant irritable bowel syndrome (IBS-C) and-diarrhea predominant IBS (IBS-D).Methods: This randomized, double-blind, two-arm, placebo-controlled parallel study randomized 92 (1:1) to receive either 500 million CFU (treatment group) or placebo (placebo twice da...

M a i n r e s u l t s 6 placebo-controlled studies involving 641 patients (326 assigned to flumazenil and 315 assigned to placebo) met the selection criteria. Treatment duration ranged from 5 minutes to 3 days. Combining data from 5 trials (317 patients assigned to flumazenil and 306 to placebo) showed that more patients who received flumazenil had clinical improvement than did those who receiv...

BACKGROUND Beta1 (B(1)) selective blockers have been widely used for the treatment of neurocardiogenic syncope though clinical trials have shown conflicting degrees of efficacy. OBJECTIVE To study the clinical efficacy of B(1) selective blockers compared to placebo in the treatment of neurocardiogenic syncope. METHODS Four placebo controlled randomized studies were identified after search o...

BACKGROUND In surveys of children with allergic rhinitis (AR), nasal congestion has been identified as the most frequently experienced and bothersome symptom. This analysis was conducted to investigate the effect of mometasone furoate nasal spray (MFNS) on congestion in children with AR. METHODS Two multicenter, double-blind, placebo-controlled studies randomly assigned children to MFNS 100 μ...

Purpose: Limited information is available on acute treatments for migraine in elderly patients. Our objective was to evaluate the tolerability and safety of lasmiditan, a serotonin 1F agonist, treatment compared with nonelderly patients, special emphasis cardiovascular-related issues because cardiovascular comorbidities are more common population.Methods: These post hoc analyses evaluated incid...

ABSTRACT: This study aimed to evaluate the effects of Reiki therapy on postoperative pain in bitches undergoing elective minimally invasive ovariohysterectomy (OVH). Thirty were randomly assigned three groups: Control, Placebo, or Reiki. All dogs received methadone as preanesthetic medication (PAM), meloxicam preoperative period, propofol for anesthetic induction, and isoflurane maintenance. Im...

This study investigated the effects of creatine and sodium bicarbonate coingestion on mechanical power during repeated sprints. Nine well-trained men (age = 21.6 ± 0.9 yr, stature = 1.82 ± 0.05 m, body mass = 80.1 ±12.8 kg) participated in a double-blind, placebo-controlled, counterbalanced, crossover study using six 10-s repeated Wingate tests. Participants ingested either a placebo (0.5 g·kg(...