Pituitary carcinomas are rare neoplasms characterized by craniospinal and/or systemic metastases originated from the pituitary. Their histopathology is frequently indistinguishable from that of benign adenomas. The development of markers that better reflect their behavior is desirable. We present the case of a 47 year-old man with a prolactin-secreting macroadenoma who was submitted to surgerie...

We report the case of a young woman who presented with an acute fulminant meningoencephalitis as the first sign of an invasive pituitary macroadenoma. This rare and dramatic complication is described in detail, and the different management steps, from the lumbar puncture to the bifrontal craniectomy, are discussed. In conclusion, this clinical presentation highlights the importance of early dia...

CONTEXT The role of dehydroepiandrosterone-sulfate (DHEA-S) in assessing the integrity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with suspected insufficiency is uncertain. OBJECTIVE The objective of the study was to prospectively evaluate the diagnostic value of DHEA-S on HPA function in consecutive patients with suspected HPA insufficiency with and without pituitary lesion...

Rubinstein-Taybi Syndrome (RSTS) is an autosomal dominant disorder that is classically characterized by prenatal and postnatal growth restriction, microcephaly, dysmorphic craniofacial features, broad thumbs and toes, and intellectual disability. We describe the first reported case of a pituitary macroadenoma associated with RSTS. A 39-year-old Caucasian female with a past medical history of RS...

Multi-secreting pituitary adenomas are relatively rare. The mixed somatotropic and corticotropic adenoma is very most widely described association that coupling hypersecretion of GH prolactin. We report the case a patient with bi-secreting ACTH. He was 28-year-old admitted for tumor syndrome, cushing syndrome. hormonal assessment found dependent ACTH other hypothalamohypophysial axes were witho...

Hyponatremiais common in neurosurgical patients especially after pituitary surgery. It is the most common electrolyte abnormality encountered in general hospital admissions. Diagnosis of the underlying cause can be challenging. It has serious clinical sequelae if not diagnosed promptly, and can be fatal. Hyponatremia can result from severe hypothyroidism and secondary adrenal insufficiency. In ...

PURPOSE We present the unusual occurrence of two distinct neoplasms in a 42-year-old woman with an operated pituitary adenoma 18 years ago. METHODS Clinical history, magnetic resonance imaging studies and histopathological findings were utilized for our diagnostic considerations. RESULTS Concomitant presence of a cerebellar medulloblastoma secondary disseminated within the spinal canal and ...

A macroprolactinoma recurred in a 25-year-old lady, who had initially presented with inability to conceive, secondary amenorrhea, galactorrhea and persistent headache. She was diagnosed as a patient of pituitary macroadenoma of 1.7 cm with elevated serum prolactin level. She was given Bromocriptine, which normalized her menstruation as well as the prolactin level followed by conception during t...