Human pluripotent stem cells (hPSCs) provide an unlimited cell source for regenerative medicine. Hormone-producing cells are particularly suitable for cell therapy, and hypopituitarism, a defect in pituitary gland function, represents a promising therapeutic target. Previous studies have derived pituitary lineages from mouse and human ESCs using 3D organoid cultures that mimic the complex event...

This in vivo experimental study was designed to investigate the effects of probucol, a hypocholesterolemic agent, on uterine adenomyosis which is frequently induced by pituitary grafting in mice. SHN mice, which are known to develop uterine adenomyosis spontaneously, and much sooner after pituitary grafting, were used and histopathological study on the uteri in pituitary gland-implanted mice wi...

The normal functions of the pituitary gland may be suppressed when the gland is compressed onto the sella floor by arachnoid tissue extending through an impaired sella diaphragm. Interestingly, pituitary hormone hypo- and hypersecretion, including acromegaly, have been observed in patients with an 'empty sella'(1-4). This 'empty sella syndrome' has been classified into a primary form, in which ...

BACKGROUNDANDPURPOSE: The pituitary gland is located outside of the blood-brain barrier. Dynamic T1 weighted contrast enhanced sequence is considered to be the gold standard to evaluate this region. However, it does not allow assessment of intrinsic permeability properties of the gland. Our aim was to demonstrate the utility of radial volumetric interpolated brain examination with the golden-an...

Pituitary tumors are benign that occur in the pituitary gland with a presentation of 10% all intracranial tumors. If size tumor is > 1 cm, called macroadenoma, large will have mass effect so there an emphasis on area and its surroundings. This manifest hyposecretion hormones produced pituitary. We report case 57-year-old male complaints decreased vision since 3.5 months. The patient had prev...

BACKGROUND Anasarca in patients with lymphoma is a rare symptom. We report a patient with DLBCL associated with pituitary gland infiltration that was diagnosed based on significant anasarca. CASE PRESENTATION A 72-year-old woman with a 10-year history of hypertension visited a local hospital presenting with anasarca and 15-kg weight gain in the past 3 months. we clinically diagnosed central h...

Exposure to light reduces the ability of the rat pineal gland to synthesize melatonin and decreases the weight of the gland. When the sympathetic nerves to the pineal gland are cut, light no longer has an effect on melatonin synthesis or pineal weight. The response of the gland does not require that the gonads or the pituitary gland be present.