Genetic suppression of insulin/insulin-like growth factor signaling (IIS) can extend longevity in worms, insects, and mammals. In laboratory mice, mutations with the greatest, most consistent, and best documented positive impact on lifespan are those that disrupt growth hormone (GH) release or actions. These mutations lead to major alterations in IIS but also have a variety of effects that are ...

prophet of pou1f1 (prop1) plays direct or indirect important roles in the morphogenesis of pituitary gonadotropes as well as lactotropes, somatotropes and caudomedial thyrotropes. it also controls the expression of growth hormone, prolactin and thyrotropin subunits through regulatory pit1 factor. these hormones have important influences on production traits in most animal species including the ...

PIT1, a member of the POU-domain family of genes, is a positive regulatory factor of growth hormone, prolactin, and thyrotroph-stimulating hormone /3 in several mammals. Therefore, PITl was chosen as a candidate gene to investigate its association with growth and carcass traits in pigs. The five Iowa State University referencehesource threegeneration families consisting of crosses of Meishan x ...

Abstract Background and Aims Chronic kidney disease (CKD) is an independent cardiovascular risk factor. The initial mechanisms of myocardial remodeling (MR) in CKD are poorly understood. major developmental signaling pathways Notch, Hedgehog, Wnt, Bmp seem to be involved many crucial steps MR (cardiomyocytes survival regeneration, fibrotic response, angiogenesis), while their role due was not p...

Abstract Hypopituitarism with deficiency of one or more pituitary hormones (combined hormone CPHD) can vary in severity and age at presentation. Additionally, the abnormalities may evolve time necessitating frequent evaluation. These hormonal deficits also be present as part a syndrome, patients showing extrapituitary such eye forebrain malformations. Over past decade, there has been an explosi...

To further elucidate pituitary adrenal interactions during development, we studied the organogenesis of the interrenal organ, the teleost homolog of the mammalian adrenal gland, in zebrafish. To this end we compared wild-type zebrafish interrenal development with that of mutants lacking pituitary cell types including corticotrophs. In addition, we studied the effects of ACTH receptor (Mc2r) kno...