In the present study, an attempt has been made to develop a high-performance thin layer chromatography fingerprinting of gallic acid, piperine and curcumin from Ayurvedic formulation, Dekofcyn tablet. Chromatographic separation was achieved on plate pre-coated with silica gel 60F254 as stationary phase. The solvent system consisted toluene:ethyl acetate:formic acid:glacial acetic acid in ratio ...

Introduction: Piperine is a compound that has many health benefits, but piperin toxic effects endanger the human body. The purpose of this study was to determine dose subchronic piperine administration using histology liver, kidneys, and lungs mice (Mus musculus L).Method: This quasi-experimental research with posttest only control group design. Thirty male BALB/c were divided into five groups....

The phytochemistry of the genus Piper (Piperaceae) has been widely studied due to the biological properties of amides from these plants. In this work, we have synthesized and evaluated the toxic effect of 11 amides against the fall armyworm Spodoptera frugiperda larvae. The naturally occurring piperine was also evaluated. The most active amide was N-[3-(3',4'-methylenedioxyphenyl)-2-(E)-propeno...

Synthetic metalloporphyrins, in the presence of monooxygen donors, are known to mimetize various reactions of cytochrome P450 enzymes systems in the oxidation of drugs and natural products. The oxidation of piperine and piplartine by iodosylbenzene using iron(III) and manganese(III) porphyrins yielded mono- and dihydroxylated products, respectively. Piplartine showed to be a more reactive subst...

Piperine (PP) is a pungent component in black pepper that possesses useful biological activities; however it is practically insoluble in water. The aim of the current study was to prepare a coground mixture (GM) of PP and β-cyclodextrin (βCD) (molar ratio of PP/βCD = 1/1) and subsequently evaluate the solubility of PP and physicochemical properties of the GM. DSC thermal behavior of the GM show...

This review focuses on the interrelationship between ageing and autophagy. There is a striking similarity between the signalling aspects of these two processes. Both ageing and autophagy involve several of the signalling components such as insulin/IGF-1, AMPK, Ras-cAMP-PKA, Sch9 and mTOR. Ageing and ageing-mediated defective autophagy involve accumulation of lipofuscin. Components of anti-agein...

OBSERVATION OF BIS-1,3-BENZODIOXONE TYPE HOMODIMER SYNTHESIZED VIA PIPERINE OLEFIN METATHESIS CATALYZED BY NON-COMMERCIAL Ru(II) PRE-CATALYSTS. LN-1 and LN-2 are two complexes coordinated to the phosphine amines simultaneously, each with chlorides. PPh3 is amine piperidine (LN-1) perhydroazepine (LN-2). The compounds five-coordinated square pyramidal geometry, in axial plane. were tested for fi...