In the title compound, C10H20N4O3, the piperazine ring adopts a chair conformation. The mol-ecule adopts an E conformation across the C=N double bond, with the -OH group and the piperazine ring trans to one another. Further, the H atom of the hy-droxy group is directed away from the NH2 group. An intra-molecular N-H⋯O contact occurs involving the NH2 group and the oxime O atom. In the crystal, ...

An efficient and alternative synthetic approach has been developed to prepare various N-(arylethyl)piperazine-2,6-diones from 4-benzenesulfonyliminodiacetic acid and primary amines using carbonyldiimidazole in the presence of a catalytic amount of DMAP at ambient temperature. Piperazine-2,6-diones are successfully transformed to pharmaceutically useful pyridopyrazines or pyrazinoisoquinolines a...

The surface tension of aqueous solutions of simple cyclic, heterocyclic and aromatic amines was measured with a Du Nöuy tensiometer at 25 degrees C and the results discussed in terms of structure-aggregation relationships. The simple compounds used in this study were piperazine, piperidine, morpholine, 3-methylpyridine, cyclohexylamine and benzylamine, with carbon numbers ranging from four to s...

A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and (1)H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MA...

In the title mol-ecule, C(17)H(18)F(2)N(2), the dihedral angle between the benzene rings is 73.40 (3)°. The piperazine ring is close to an ideal chair conformation and the N-H hydrogen is in an equatorial position. In the crystal, molecules are linked via weak C-H⋯F hydrogen bonds.

In the title compound, (C(7)H(18)N(2))[ZnCl(4)], the Zn atom adopts a slightly distorted tetra-hedral geometry. The diprotonated piperazine ring adopts a chair conformation. In the crystal structure, the cations and anions are linked by inter-molecular N-H⋯Cl hydrogen bonds into a chain along [001].

In the title mol-ecule, C(13)H(15)ClF(2)N(2)O, the piperazine ring is in a chair conformation with the 2,4-difluoro-benzyl and chloro-acetyl substituents in equatorial positions.

In the title compound, C(18)H(22)N(2), which possesses non-crystallographic inversion symmetry, the central piperazine ring adopts a chair conformation. The phenyl rings are not exactly parallel and make a dihedral angle of 1.3 (1)°. No significant inter-molecular contacts are observed in the crystal.

In the title compound, C(19)H(20)F(2)N(2)O, the six-membered piperazine group adopts a slightly distorted chair conformation. The dihedral angle between the mean planes of the two benzene rings is 73.4 (6)°. The mean plane of the ethanone group is twisted from the mean planes of the two benzene rings by 66.7 (8) and 86.2 (6)°. In the crystal, C-H⋯O and C-H⋯F inter-actions link the molecules, fo...

In the cation of the title salt, C9H13N2O2 (+)·C7H3N2O6 (-), the piperazine ring adopts a slightly distorted chair conformation. Twofold rotational disorder is exhibited by the furan ring in a 0.430 (4):0.570 (4) ratio. In the crystal, N-H⋯O hydrogen bonds link the ions into chains along [010]. Additional weak C-H⋯O inter-actions are observed, leading to a supra-molecular layer parallel to (011).