}iperacillin/tazobactam (ZOSYN, Lederle Laboratories, Pearl River, NY) is the most recently approved combination of a [3-1actam antimicrobial agent with an inhibitor of bacterial [3-1actamases. In vitro and clinical studies have demonstrated efficacy in polymicrobial infections such as obstetric, gynecologic, and soft-tissue infections. Piperacillin/ tazobactam appears to be an appropriate drug...

OBJECTIVE To describe a pharmacokinetic model of piperacillin concentrations in plasma and subcutaneous tissue when administered by bolus dosing and continuous infusion in critically ill patients with sepsis on days 1 and 2 of antibiotic therapy and to compare results against previous results for piperacillin from a cohort of patients with septic shock. DESIGN Prospective randomized controlle...

BACKGROUND & OBJECTIVE Production of extended spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases are the most common mechanisms of antimicrobial resistance in Gram negative bacilli. A prospective study was undertaken to know the occurrence of ESBL and AmpC producing strains and their antibiotic susceptibilities to newer agents to guide empirical therapy for complicated urinary tract infe...

Delayed-type cutaneous drug hypersensitivity is a T-cell mediated disease; the spectrum of conditions has been classified according to the phenotype and function of drug antigen-specific T-cells sub-sets. Importantly, this classification does not take into account tissue-specific cytokines such as interleukin-17 and interleukin-22. Both of these cytokines have been shown to play a role in numer...

Agar dilution MIC methodology was used to compare the activity of sulopenem with those of amoxicillin/clavulanate, ampicillin/sulbactam, piperacillin-tazobactam, imipenem, clindamycin, and metronidazole against 431 anaerobes. Overall, MIC(50)/(90) values were as follows: sulopenem, 0.25/1.0 microg/ml; amoxicillin/clavulanate, 0.5/2.0 microg/ml; ampicillin/sulbactam, 0.5/4.0 microg/ml; piperacil...

The objective of the present study was to analyze the susceptibility profiles of 911 clinical strains of the Bacteroides fragilis group isolated from 1992 to 1997 in our institution in order to monitor susceptibility changes over time. Whereas the rates of resistance to metronidazole, imipenem, piperacillin-tazobactam, ticarcillin-clavulanic acid, penicillin, piperacillin, and cefoxitin remaine...

A study of antimicrobial agents sensitivity using the microdilution system incorporated to identification/susceptibility of non-fermenting gram-negative of Microscan panels, was made, taking into account the breakpoints in the Clinical and Laboratory Standards Institute (CLSI). Studied strain was sensitive to most of the antibiotics tested as: cefotaxime, cefepime and piperacillin/tazobactam, g...

ACHN-490 was tested alone and in combination with cefepime, doripenem, imipenem, or piperacillin-tazobactam in a synergy time-kill analysis against 25 Pseudomonas aeruginosa strains with different resistance phenotypes. Each combination was synergistic against most isolates at 24 h, and antagonism was not observed. Combinations of ACHN-490 with cefepime, doripenem, imipenem, or piperacillin-taz...

A microbroth dilution method was used to measure the MICs of cefpiramide (SM 1652), cefotaxime, moxalactam, ceftazidime, cefoperazone, ceftriaxone, piperacillin, and mezlocillin against 921 isolates of gram-negative (701) and gram-positive (220) bacteria. The activity of cefpiramide was equivalent to those of piperacillin and mezlocillin against members of the family Enterobacteriaceae and gram...