Background: Epilepsy is a severe neurological condition that affects all ages of people. Complex pathways involved in pathogenesis make it complicated to treat; selected antiepileptic drug options are available for Epilepsy. There need an hour develop novel treatment approaches epilepsy with lesser side effects. This research aimed evaluate the alleviating role bio-enhancers co-administered lev...

introduction: radioisotope scanning is the best method for objective assessment of salivary gland function. thus, it was used in a randomized trial of concomitant pilocarpine for assessment of radiation-induced xerostomia, in addition to subjective evaluation by an approved questionnaire and objective standard xerostomia grading. methods: patients randomized in placebo-controlled trial of piloc...

Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy. We have studied the effects of cannabidiol (CBD) on the ability to produce long term potentiation (LTP) in stratum radiatum of CA1 region of the mouse hippocampus. Exposure to seizure-producing pilocarpine r...

Pupillary responses to pilocarpine following topical application in a novel ophthalmic delivery system (NODS) and a conventional eyedrop formulation have been compared in eight healthy subjects in a single dose crossover study. The magnitude of the miotic and light reflex responses to NODS 40, 80, and 170 micrograms and to a single 2% Minims eyedrop (delivering 518 micrograms) were recorded by ...

Facility of outflow in the eye of the vervet monkey Cercopithecus ethiops was studied by constant-rate and by constant-pressure infusion. Facility increased greatly after the injection of 2 to 3 fig of pilocarpine into the anterior chamber or after the application of 0.2 to 0.3 ing. to the cornea. The effect on facility consisted of 2 components. One component was reversed in 3 to 5 minutes by ...

Ciliary muscle topography was studied in rhesus monkey eyes (aged 6 to 29 years) bisected meridionally through cornea and optic nerve head. Half of each eye was incubated in atropine sulfate, the other in pilocarpine hydrochloride, and both were then processed for histologic study. Several ciliary muscle sections from the original cut margin and the middle of the half eyes were traced and compa...