Picornavirus mRNAs contain IRESs that sustain their translation during infection, when host protein synthesis is shut off. The major classes of picornavirus IRESs (Types 1 and 2) have distinct structures and sequences, but initiation on both is determined by their specific interaction with eIF4G. We report here that Aichivirus (AV), a member of the Kobuvirus genus of Picornaviridae, contains an...

Human rhinoviruses (HRVs) are positive-stranded RNA viruses belonging to the Enterovirus genus in the family of Picornaviridae. Identification of the specific strain in HRV disease has been difficult because the traditional serological method is insensitive, labor intensive, and cumbersome. With the fast progress in molecular biological technique, more sensitive and faster molecular methods hav...

In this work, we determined the diversity and dynamics of gut virome infants during first year life. Fecal samples were collected monthly, from birth to one age, three healthy children living in a semi-rural village Mexico. Most viral reads classified into six families bacteriophages including five dsDNA virus order Caudovirales , with Siphoviridae Podoviridae being most abundant. Eukaryotic vi...

RNA labeled with [3H]uridine from Vero cells infected with San Miguel sea lion virus in the presence of actinomycin D was analyzed by glycerol density gradient sedimentation and polyacrylamide gel electrophoresis. The predominant single-stranded RNA (36S, 2.6 x 10(6) molecular weight) was genome size. There was also a prominent 22S, 1.1 x 10(6)-molecular weight, single-stranded component and on...

Recently, Manila clam, Ruditapes philippinarum, populations have suffered mortalities in Arcachon Bay (SW France). Mortality was associated with extensive lesions of the posterior adductor muscle, which become progressively brown and calcified. Ultrastructural observations by transmission electron microscopy revealed tissue degradation with necrotized muscle fibres and granulocytomas. Unenvelop...

Coxsackievirus B5 (CVB5), a human enterovirus of the family Picornaviridae, is a frequent cause of acute and chronic human diseases. The pathogenesis of enteroviral infections is not completely understood, and the fate of the CVB5-infected cell has a pivotal role in this process. We have investigated the CVB5-induced apoptosis of HeLa cells and found that it happens by the intrinsic pathway by ...

Poliovirus is a single stranded RNA virus, a member of the family Picornaviridae, genus poliovirus. There are three strains poliovirus types 1-3. Poliovirus is an important cause of acute flaccid paralysis (AFP), which when attributable to poliovirus is known as paralytic poliomyelitis. Paralytic poliomyelitis follows approximately 0.1-2% of poliovirus infections and typically presents as an ac...

Viruses containing RNA genomes, or RNA viruses, constitute an extensive genetic group of plant, animal, and human viruses. RNA viruses include many viruses that are important human pathogens, and have been shown to have the ability to move from animals to humans, resulting in zoonotic-human epidemics. RNA viruses that contain single-stranded RNA genomes of positive polarity are known as positiv...

INTRODUCTION: The poliovirus is a nonenveloped plus-strand RNA virus belonging to Picornaviridae, and is the causative pathogen of paralytic poliomyelitis. The selective targeting of motor neurons by poliovirus is most likely determined by the distribution of its cellular receptor, the Ig superfamily molecule CD155 (also known as poliovirus receptor: PVR). Recently, a number of reports have ind...