Fundamental mathematical constants like $e$ and $\pi$ are ubiquitous in diverse fields of science, from abstract mathematics to physics, biology chemistry. For centuries, new formulas relating fundamental have been scarce usually discovered sporadically. Here we propose a novel systematic approach that leverages algorithms for deriving help reveal their underlying structure. Our find dozens wel...

UNLABELLED PURPOSE. This study was performed to characterize the clinical, serologic, histopathologic, and immunohistochemical features of an experimental model of ocular toxoplasmosis in cats. METHODS Seven specific pathogen-free cats were inoculated in the right carotid artery with 5 x 10(3) tachyzoites of the ME49 strain of Toxoplasma gondii. Control cats received heat-killed tachyzoites. ...

An increasing number of studies have linked high dietary phosphate (Pi) intake to hypertension. It is well established that the rise in sympathetic nerve activity (SNA) and blood pressure (BP) during physical exertion is exaggerated in many forms of hypertension, which are primarily mediated by an overactive skeletal muscle exercise pressor reflex (EPR). However, it remains unknown whether high...

conclusions our results indicated that the dissemination of pi-1 was widespread in s. pneumoniae isolates, although no pi-2 isolates were detected. furthermore, the frequency of rlra and rrgc of clinical isolates was significantly more than that of normal flora isolates. results the results confirmed the presence of rlra and rrgc genes in both clinical (n = 39) and normal flora (n = 26) isolate...

We examined the effect of glucocorticoids on brush border membrane transporters and, furthermore, the involvement of Ca2+ in its action in the primary cultured rabbit renal proximal tubule cells (PTCs). Dexamethasone (DEX, 10(-9) M) decreased Pi uptake by 17%; whereas DEX affected neither alpha-methyl-glucopyranoside (alpha-MG) uptake nor Na+ uptake. The DEX-induced inhibition of Pi uptake was ...

Real-life data showed an increased incidence of bacterial infections in patients with advanced liver disease receiving a protease inhibitor (PI)-containing antiviral regimen against hepatitis C (HCV). However, the causes of this event are unknown. We hypothesized that PIs might impair innate immune responses through the inhibition of proteases participating in the anti-bacterial functions of ne...

Murthy, Karnam S., Huiping Zhou, Jiean Huang, and Srinivas N. Pentyala. Activation of PLC1 by Gi/o-coupled receptor agonists. Am J Physiol Cell Physiol 287: C1679–C1687, 2004; doi:10.1152/ ajpcell.00257.2004.—The mechanism of phospholipase (PLC)activation by G protein-coupled receptor agonists was examined in rabbit gastric smooth muscle. Ca stimulated an eightfold increase in PLC1 activity in ...

Abstract The multihadron decays $$ {\Lambda}_b^0 Λ b 0 → D + pπ−π− and * are observed in data corresponding to an integrated luminosity of 3 fb − 1 , collected proton-proton collisions at centre-of-mass energies 7 8 TeV by the LHCb detector. Using...

Cell membrane phospholipids, like phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)], can regulate epithelial Na channel (ENaC) activity. Gender differences in lung ENaC expression have also been demonstrated. However, the effects in vivo on alveolar fluid clearance are uncertain. Thus PI(4,5)P(2) effects on alveolar fluid clearance were studied in male and female rats. An isosmolar 5% albumin...