In addition to interacting with functional proteins such as receptors, ion channels, and enzymes, a variety of drugs mechanistically act on membrane lipids to change the physicochemical properties of biomembranes as reported for anesthetic, adrenergic, cholinergic, non-steroidal anti-inflammatory, analgesic, antitumor, antiplatelet, antimicrobial, and antioxidant drugs. As well as these membran...

Jew's mallow (Corchorus olitorius L.) leaves powder was added to rice flour at levels of 0% to 5% and extruded in single screw extruder to produce healthy extrudates. Process variables (feed moisture, feed rate, screw speed and temperature) were kept constant. The effects of adding Jew's mallow leaves on functional properties, color attributes, some phytochemicals contents, antioxidant activity...

Fruits, vegetables, spices, herbs and/or beverages are typical foods containing various phytochemicals that have been used for prevention and treatment of a variety of human ailments since time immemorial. Nowadays, a large number of individuals are motivating towards the use of phytochemicals inorder to prevent or treat chronic diseases. Recent research efforts have been greatly emphasized on ...

Plant secondary metabolites, which include a wide variety of phytochemicals, have always been constituents of the diets of man and other animals. Although a high proportion of these phytochemicals have been considered to be of little value in plants (although this view is changing), they have frequently been shown to have adverse effects on animals when ingested. The effects depend to a great e...

Endogenous noninfectious substances that mediate the nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation and interleukin (IL)-1β secretion causes inappropriate sterile inflammation and is implicated in the pathogenesis of several chronic diseases, such as type 2 diabetes mellitus, gout, atherosclerosis and Alzheimer's disease. C...

The theory that several carcinogenetic processes are initiated and sustained by cancer stem cells (CSCs) has been validated, and specific methods to identify the CSCs in the entire population of cancer cells have also proven to be effective. This review aims to provide an overview of recently acquired scientific knowledge regarding phytochemicals and herbal extracts, which have been shown to be...

Methicillin resistant Staphylococcus aureus (MRSA) infection is a global concern nowadays. Due to its multi-drug resistant nature, treatment with conventional antibiotics does not assure desired clinical outcomes. Therefore, there is a need to find new compounds and/or alternative methods to get arsenal against the pathogen. Combination therapies using conventional antibiotics and phytochemical...

BACKGROUND Salix aegyptiaca is known for its medicinal properties mainly due to the presence of salicylate compounds. However, it also contains other beneficial phytochemicals such as gallic acid, quercetin, rutin and vanillin. The aim of the study was to examine the redox potential, antioxidant and anti-inflammatory activity of these phytochemicals along with acetylsalicylic acid. METHODS Th...

The “Mitochondrial Free Radical Theory of Aging” (MFRTA) hypothesizes that reactive oxygen species (ROS) arising from aged and/or defective mitochondria are associated with the pathogenesis of various age-related diseases. The glutathione antioxidant response, in particular glutathione redox cycling, is a critical mechanism for protection against ROS-induced cell death. Over the past few decade...

In the present study, two chloroform extracts of fruits of Terminalia chebula viz. "CHL1" and "CHL 2" prepared by maceration and sequential method respectively was compared for their antioxidant efficacy and phenolic content. The extraction procedure of plant material plays an important role in the activity of phytochemicals. Also, the assessment of antioxidant capacity of phytochemicals cannot...