Although many sequences and linear IgE epitopes of allergenic proteins have been identified and archived in databases, structural and physicochemical discriminators that define their specific properties are lacking. Current bioinformatics tools for predicting the potential allergenicity of a novel protein use methods that were not designed to compare peptides. Novel tools to determine the quant...

Sequence analysis often does not take the physicochemical properties into account. On the other hand, some of these properties could be useful in inferring the folding and functional attributes of the molecule when considered with the original sequence information. We evaluated here an analysis using multiple aligned sequences incorporating five physicochemical properties. In addition to site i...

Which intrinsic biomaterial parameter governs and, if quantitatively monitored, could reveal to us the actual lifetime potential of advanced hip joint bearing materials? An answer to this crucial question is searched for in this paper, which identifies ceramic bearings as the most innovative biomaterials in hip arthroplasty. It is shown that, if in vivo exposures comparable to human lifetimes a...

We describe the molecular dynamics (MD)-aided engineering design of mutant peptides based on the alpha-helical coiled-coil GCN4 leucine zipper peptide (GCN4-p1) in order to obtain environmentally-responsive nanotweezers. The actuation mechanism of the nanotweezers depends on the modification of electrostatic charges on the residues along the length of the coiled coil. Modulating the solution pH...

The physicochemical properties of bovine prothrombin and of bovine thrombin were previously described in this journal (1, 2). A derivative of bovine prothrombin, autoprothrombin II, has now been obtained in sufficient quality and quantity for study. In this report we describe some of the physicochemical properties of our product, including sedimentation coefficient, diffusion coefficient, intri...

The long-term use of polyethylene mulch (PEM) films can cause plastic film residual pollution that has an adverse effect on soil health and crop quality. To address this issue, poly(butylene adipate-co-terephthalate) (PBAT), aliphatic–aromatic copolyester, is widely used in the production commercially biodegradable (BDM) films. BDMs alleviate reduce labor cost retrieving residues from field. ef...

Olive oil is an important component of Mediterranean diet widely, consumed thanks to its numerous health-healing properties. Its quality dependent upon a set factors (genotypic, environmental, agronomic practices, ripening, etc). These are well documented, but little known about the impact extraction technology on ‘Moroccan Picholine’ olive quality. In this paper, physicochemical traits (cv Pic...