The hydrophobic part of the solvent-accessible surface of a typical monomeric globular protein consists of a single, large interconnected region formed from faces of apolar atoms and constituting approximately 60% of the solvent-accessible surface area. Therefore, the direct delineation of the hydrophobic surface patches on an atom-wise basis is impossible. Experimental data indicate that, in a...

The purpose of this study was to design novel drug delivery system containing Lornoxicam microsponges. Lornoxicam is a Non-steroidal anti-inflammatory drug used for the treatment of various inflammatory diseases. Microsponges containing Lornoxicam and Eudragit RS 100 were prepared by quasi emulsion solvent diffusion method. The effects of drug to polymer ratios on physical characteristics of th...

The aim of the present study was to improve solubility and dissolution of the poorly aqueous soluble drug, etoricoxib by solvent evaporation technique using various sugar carriers, such as lactose, sucrose, and mannitol. Etoricoxib solid dispersions and their respective physical mixtures using lactose, sucrose, and mannitol were prepared in different ratios by solvent evaporation technique. The...

P Biman Bagchi has made pivotal contributions to the area of dynamics of chemical and biological systems in an academic career spanning more than three decades. He has been a great teacher and mentor for a large number of young theoretical physical chemists of India and a creative and insightful collaborator with leading scientists worldwide. We take great pride in guest editing this special is...

There are many ways to coat tablets. Coatings are a very important part in the formulation of pharmaceutical dosage form to achieve excellent formulation quality (e.g., color, texture, mouth feel, and taste masking), physical and chemical protection for the drugs in the dosage forms, and modification of drug release characteristics. Most film coatings are applied as aqueous or organic-based pol...

The hydrophobic interaction, the tendency for nonpolar molecules to aggregate in solution, is a major driving force in biology. In a direct approach to the physical basis of the hydrophobic effect, nanosecond molecular dynamics simulations were performed on increasing numbers of hydrocarbon solute molecules in water-filled boxes of different sizes. The intermittent formation of solute clusters ...

The aim of this study was to investigate the effects of solid carriers and processing routes on the properties of amorphous solid dispersions of itraconazole. Three solid carriers with a range of surface properties were studied, (1) a mesoporous silicate, magnesium aluminum silicate (Neusilin US2), (2) a nonporous silicate of corresponding composition (Veegum) and (3) a non-silicate, inorganic ...

Bagasse flour (BF) was liquefied using bi-component polyhydric alcohol (PA) as a solvent and phosphoric acid as a catalyst in a microwave reactor. The effect of BF to solvent ratio and reaction temperatures on the liquefaction extent and characteristics of liquefied products were evaluated. The results revealed that almost 75% of the raw bagasse was converted into liquid products within 9 min a...

The aim of this study was to develop an efficient enzymatic glycerolysis system together with physical fractionation operation for the production of monoacylglycerols (MAG) containing polyunsaturated fatty acids (PUFA), especially, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from tuna oil. The enzymatic glycerolysis system at 40-70 °C is unfortunately a multiple-phase system, whi...