نتایج جستجو برای: phosphoryl

تعداد نتایج: 1670  

Journal: :Applied and environmental microbiology 2010
M G Baker S V Lalonde K O Konhauser J M Foght

Bacterial surface layers, such as extracellular polymeric substances (EPS), are known to play an important role in metal sorption and biomineralization; however, there have been very few studies investigating how environmentally induced changes in EPS production affect the cell's surface chemistry and reactivity. Acid-base titrations, cadmium adsorption assays, and Fourier transform infrared sp...

Journal: :The Analyst 2011
Sanela Martić Mahmoud Labib Heinz-Bernhard Kraatz

We hereby present an electrochemical approach for monitoring the three protein kinases sarcoma-related kinase (Src), extracellular signal-regulated kinase 1 (Erk1), and cyclin A-dependent kinase 2 (CDK2/cyclin A). The electrochemical sensor is based on the ability of kinases to transfer a redox-labeled phosphoryl group to surface-bound peptides that are highly specific substrates for the partic...

1998
Barbra M. Fisher Ronald T. Raines

The interaction between bovine pancreatic ribonuclease A (RNase A) and its RNA substrate extends beyond the scissile bond. Enzymic subsites interact with the bases and the phosphoryl groups of a bound substrate. We evaluated the four cationic residues closest to known subsites for their abilities to interact with a bound nucleic acid. Lys-37, Arg-39, Arg-85, and Lys-104 were replaced individual...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Y Pazy M A Motaleb M T Guarnieri N W Charon R Zhao R E Silversmith

Two-component signal transduction systems are widespread in prokaryotes and control numerous cellular processes. Extensive investigation of sensor kinase and response regulator proteins from many two-component systems has established conserved sequence, structural, and mechanistic features within each family. In contrast, the phosphatases which catalyze hydrolysis of the response regulator phos...

Journal: :Current Biology 1997
Alfred Wittinghofer

Recent three-dimensional structures of phosphoryl transfer enzymes in their aluminum fluoride bound state and corresponding biochemical data have shown how diverse biological problems can be investigated using this small inorganic molecule.

Journal: :Chemical communications 2005
Carla Bazzicalupi Andrea Bencini Antonio Bianchi Andrea Danesi Claudia Giorgi Carlos Lodeiro Fernando Pina Samuele Santarelli Barbara Valtancoli

A protonated Zn(II) complex with a terpyridine-containing pentaamine macrocycle catalyses ATP hydrolysis in the presence of a second metal ion, which acts as cofactor assisting the phosphoryl transfer from ATP to an amine group of the receptor.

2010
Vladimir A. Ovchynnikov

In the title compound, C(16)H(17)Cl(3)N(3)O(2)P, the P atom has a slightly distorted tetra-hedral configuration. The conformations of the carbonyl and phosphoryl groups are anti to each other. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into infinite chains parallel to the b axis.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
P Heikinheimo V Tuominen A K Ahonen A Teplyakov B S Cooperman A A Baykov R Lahti A Goldman

The wealth of kinetic and structural information makes inorganic pyrophosphatases (PPases) a good model system to study the details of enzymatic phosphoryl transfer. The enzyme accelerates metal-complexed phosphoryl transfer 10(10)-fold: but how? Our structures of the yeast PPase product complex at 1.15 A and fluoride-inhibited complex at 1.9 A visualize the active site in three different state...

Journal: :The Journal of organic chemistry 2003
Yu Liu Li Li Xiao-Yun Li Heng-Yi Zhang Takehiko Wada Yoshihisa Inoue

Two novel phosphoryl-bridged bis- and tris(beta-cyclodextrin)s of different tether lengths, i.e., bis[m-(N-(6-cyclodextryl)-2-aminoethylaminosulfonyl)phenyl]-m-(chlorosulfonyl)phenylphosphine oxide (5) and tris[m-(N-(6-cyclodextryl)-8-amino-3,6-diazaoctylaminosulfonyl)phenyl]phosphine oxide (6), have been synthesized by reactions of 6-oligo(ethylenediamino)-6-deoxy-beta-cyclodextrins with tris[...

Journal: :Biochemistry 2011
Saugata Hazra Andrzej Szewczak Stephan Ort Manfred Konrad Arnon Lavie

Deoxycytidine kinase (dCK) uses either ATP or UTP as a phosphoryl donor to catalyze the phosphorylation of nucleoside acceptors. The kinetic properties of human dCK are modulated in vivo by phosphorylation of serine 74. This residue is a part of the insert region and is distant from the active site. Replacing the serine with a glutamic acid (S74E variant) can mimic phosphorylation of Ser74. To ...

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