نتایج جستجو برای: phosphatidylinositol kinase
تعداد نتایج: 233279 فیلتر نتایج به سال:
Autism spectrum disorder (ASD) is a series of neurodevelopmental disorders presented as behavioral abnormality such problems with social, communication, and repetitive behaviors. There are four ASD-related monogenetic diseases worthy analysis: fragile X syndrome, PTEN hamartoma tumor tuberous sclerosis complex, Rett syndrome. These respectively caused by one gene have something in common phenot...
Background: Pre-therapeutic analysis of three-dimensional spheroid cultures primary tumour samples is a promising approach assessing susceptibility to potential treatment. The phosphatidylinositol-3-kinase/AKT serine/threonine kinase/mammalian target rapamycin (PI3K/AKT/mTOR) signalling pathway frequently activated in colorectal cancer (CRC). In previous work, we showed combined inhibition AKT ...
Insulin signaling pathways potentially involved in regulation of skeletal muscle glycogen synthase were compared in differentiated human muscle cell cultures from nondiabetic and type 2 diabetic patients. Insulin stimulation of glycogen synthase activity as well as phosphorylation of MAPK, p70 S6 kinase, and protein kinase B (Akt) were blocked by the phosphatidylinositol 3-kinase inhibitors wor...
Metabolic syndrome patients have insulin resistance, which causes hyperinsulinemia, which in turn causes aberrant increased renal sodium reabsorption. The precise mechanisms underlying this greater salt sensitivity of hyperinsulinemic patients remain unclear. Abnormal activation of the recently identified with-no-lysine kinase (WNK)-oxidative stress-responsive kinase 1 (OSR1)/STE20/SPS1-related...
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