Effects of Lead on the Induction of Hepatic Microsomal Enzymes by Phenobarbital and 3,4Benzpyrene. CHOW, C. P. AND CORNISH, H. H. (1978). Toxicol. Appl. Pharmacol. 43,219-228. A single ip injection of lead acetate (65 mg/kg) prolonged the duration of zoxazolamine paralysis in Sprague-Dawley rats and prevented the stimulation of zoxazolamine metabolism normally induced by phenobarbital. Lead als...

Pseudolymphoma is a drug reaction to anti-epileptics that is well recognized in humans; it has been reported in one cat but not dogs. In this report, lymphoma-like clinical signs are suspected to be secondary to phenobarbital administration in a dog. A 2.5-year-old male, neutered Shepherd mix presented for a 3-day history of progressive ataxia, dazed mentation, pyrexia, and lethargy. While hosp...

Calcium-dependent action potentials were recorded from mouse spinal cord neurons in primary dissociated cell culture following addition of the potassium channel blockers tetraethylammonium ion and 3-aminopyridine. The pharmacologically active barbiturates, pentobarbital and phenobarbital, but not the pharmacologically inactive barbiturate, barbituric acid, produced reversible, dose-dependent re...

To the Editor: We report our experience with 5-ethyl5-p-tolyl barbituric acid (EPTB) as an internal standard for estimating serum phenobarbital and the problem we encountered with sera containing theophylline or caffeine, or both. Phenobarbital decomposes quite erratically in the presence of water and alkaline methylating agenth during oncolumn gas-liquid chromatographic methylation (1-3). Beca...

Editorials 871 Epilepsy affects more than 60 million people worldwide, and over 80% of them live in resource-poor countries. 1 Approximately 85% of these people do not receive appropriate treatment 2 because of economic, cultural, social and legislative barriers, compounded by little interest on the part of pharmaceutical companies because drug distribution is not lucrative. Left untreated, peo...

OBJECTIVE To assess the efficacy of phenobarbital treatment for epileptic patients in rural Mali. METHODS Epileptic patients were treated at home with phenobarbital at daily dosages ranging from 50 mg for children to 200 mg for adults and their condition was monitored. Advice was given to patients, their families, and the village authorities in order to achieve compliance. An uninterrupted su...

BACKGROUND Acute alcohol withdrawal syndrome (AAWS) is encountered in patients presenting acutely to the Emergency Department (ED) and often requires pharmacologic management. OBJECTIVE We investigated whether a single dose of intravenous (i.v.) phenobarbital combined with a standardized lorazepam-based alcohol withdrawal protocol decreases intensive care unit (ICU) admission in ED patients w...