This report details discussions held over three days, August 4–6, 2014, in Ann Arbor, MI, on current research on in vivo predictive dissolution (IPD) testing. Participants hailed from academia, industry, and governmental bodies, and focused their attention on the role of IPD in various drug products. Academia was well represented at this conference with speakers mainly from the University of Mi...

Carbenicillin was introduced in therapeutics in 1967 and was especially useful, on its own or when associated with aminoglycosides, for the treatment of infections caused by Pseudomonas aeruginosa (23), a well-recognized nosocomial pathogen with intrinsic resistance to various antimicrobial agents and the ability to develop multidrug resistance (18). Nevertheless, an increasing frequency of P. ...

Previously we quantified the amounts of immunoreactive apo[ a] found in human atherosclerotic lesions extracted sequentially with phosphate-buffered saline (PBS) and guanidine hydrochloride (GuHCI). In this study we have attempted to characterize lipoproteins containing apo[a] in such PBS and GuHCl fractions, obtained from autopsy samples, in order to eventually determine their structure-functi...

Substituted 3 -thiourea derivatives of -thymidine (dThd) and 5 -thiourea derivatives of -dThd have been evaluated for their inhibitory activity against recombinant human cytosolic dThd kinase-1 (TK-1), human mitochondrial TK-2, herpes simplex virus type 1 (HSV-1) TK, and varicella-zoster virus TK. Several substituted 3 -thiourea derivatives of -dThd proved highly inhibitory to and selective for...

The purpose of this study was to determine whether poor readers have more pronounced problems than average-reading peers reading derived words whose base forms undergo a phonological shift when a suffix is added (i.e., shift relations as in natural), as compared to derived words whose forms are phonologically and orthographically transparent (i.e., "stable" relations, as in cultural). Two compu...