Background . Prostate cancer (PCa) is the most common human worldwide. In progression of prostate cancer, total number macrophages in tumor tissue associated with poor prognosis and increased risk metastasis. However, heterogeneity intratumoral at various stages PCa development, role tumor-associated (TAMs) have been insuffciently investigated. The aim study was to analyze morphological feature...

Nathan Wolfe and colleagues’ report on infection of human beings with simian foamy viruses (Mar 20, p 932) has relaunched the discussion about simian retrovirus infections as zoonoses. This concept was generated by tracing HIVs to simian sources in Africa. Although the simian origin of HIV, human T-cell lymphotropic virus (HTLV), and now foamy viruses is acknowledged, the hypothesis that retrov...

We discuss the diagnosis of and efficacy 5-amino-2-hydroxybenzoic acid (5-ASA), Saccharomyces boulardii, or magnesium in therapy of microscopic colitis with presence of foamy macrophages. A basis for diagnosis and inclusion to the analysed group was presence of characteristic foamy macrophages in histopathological examination of hematoxylin and eosin-stained specimens collected from the large i...

1 Prototype Foamy Virus (PFV) Gag nuclear localization – A novel pathway among 1 retroviruses 2 3 Erik Müllers, Kristin Stirnnagel, Sylvia Kaulfuß, and Dirk Lindemann* 4 5 Institut für Virologie, Medizinische Fakultät "Carl Gustav Carus", Technische Universität 6 Dresden, Dresden, CRTD / DFG-Center for Regenerative Therapies Dresden Cluster of 7 Excellence, Biotechnology Center, Dresden, German...

AIM To examine peripheral blood and skeletal muscle from patients with chronic fatigue syndrome for exogenous retrovirus. METHODS Blood samples from 30 patients and muscle biopsy specimens of 15 patients were examined for retroviral sequences by DNA extraction, polymerase chain reaction (PCR), and Southern blotting hybridisation. Sera were examined for human foamy virus by western immunoblott...

Foamy viruses are frequently found in non-human primates and apes in captivity. However, data on simian foamy virus (SFV) infection in apes from the wild are limited. Necropsy specimens were collected from 14 West African chimpanzees (Pan troglodytes verus) from three communities in the Taï National Park, Côte d'Ivoire. PCR analysis revealed SFV-related int- and env-specific sequences in 12/14 ...

The interactions between a retrovirus and host cell chromatin that underlie integration and provirus expression are poorly understood. The prototype foamy virus (PFV) structural protein GAG associates with chromosomes via a chromatin-binding sequence (CBS) located within its C-terminal region. Here, we show that the PFV CBS is essential and sufficient for a direct interaction with nucleosomes a...

The zoonotic introduction of an animal pathogen into the human population and the subsequent extension or alteration of its host range leading to the successful maintenance of the corresponding pathogen by human-to-human transmission pose a serious risk for world-wide health care. Such a scenario occurred for instance by the introduction of simian immunodeficiency viruses into the human populat...