نتایج جستجو برای: pharmacokinetic studies

تعداد نتایج: 1444479  

Journal: :Indian Journal of Pharmaceutical Education and Research 2020

Journal: :The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 2012
Joanie K Tulloch Roxane R Carr Mary H H Ensom

BACKGROUND Neonatal seizures are associated with neurological sequelae and an increased risk of epilepsy later in life. Phenobarbital and phenytoin remain the antiepileptic drugs (AEDs) most commonly used to treat neonatal seizures, despite their suboptimal effectiveness and safety. As a result, other AEDs, such as levetiracetam and topiramate, are often used in neonates with refractory seizure...

Journal: :Critical reviews in toxicology 2006
Hugh A Barton Timothy P Pastoor Karl Baetcke Janice E Chambers Janet Diliberto Nancy G Doerrer Jeffrey H Driver Charles E Hastings Seshadri Iyengar Robert Krieger Bernhard Stahl Charles Timchalk

A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoin...

Journal: :Drug Metabolism and Pharmacokinetics 1994

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